Professor In Residence
M_MED-ZSFG-PULM
I have a particular interest in clinical management of multidrug resistant tuberculosis (MDR-TB) in high HIV burden settings in Southern Africa. My research includes the development of non-invasive pharmacokinetic measures to enhance MDR-TB drug development and clinical trials. I am a member of the AIDS Clinical Trials Group TB Transformative Science Group, and have specialized training in epidemiology, statistical prediction, and diagnostic test evaluation. I am a specialty editor for respiratory diseases at PLoS Medicine.
Publications
Bedaquiline resistance in patients with Xpert MTB/RIF Ultra-tested rifampicin-resistant tuberculosis in the Western Cape, South Africa: a prospective study.
The Lancet. Microbe
CountFU: Ditching CFUs for qPCR enumeration of Mycobacterium tuberculosis and a call to join the revolution.
Tuberculosis (Edinburgh, Scotland)
A 3-month clofazimine-rifapentine-containing regimen for drug-susceptible tuberculosis versus standard of care (Clo-Fast): a randomised, open-label, phase 2c clinical trial.
The Lancet. Infectious diseases
Unpacking bedaquiline heteroresistance: the importance of intermediate profiles for phenotypic drug susceptibility testing.
Antimicrobial agents and chemotherapy
Xpert MTB/RIF Ultra-resistant and MTBDRplus-susceptible rifampicin results in people with tuberculosis: utility of FluoroType MTBDR and deep sequencing.
Antimicrobial agents and chemotherapy
The Hidden Epidemic of Isoniazid-Resistant Tuberculosis in South Africa.
Annals of the American Thoracic Society
Conjugated hyperbilirubinemia associated with accidental rifapentine overdose.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Frequency, kinetics and determinants of viable SARS-CoV-2 in bioaerosols from ambulatory COVID-19 patients infected with the Beta, Delta or Omicron variants.
Frontiers in medicine
Catastrophic costs among tuberculosis-affected households in Zimbabwe: A national health facility-based survey.
Transfusion science
Health care seeking patterns of rifampicin-resistant tuberculosis patients in Harare, Zimbabwe: A prospective cohort study.
Research Square
Xpert MTB/RIF-detected Rifampicin Resistance is a Sub-Optimal Surrogate for Multidrug Resistant Tuberculosis in Eastern Democratic Republic of the Congo: Diagnostic and Clinical Implications.
The American journal of tropical medicine and hygiene
Distinct lung microbiota associate with HIV-associated chronic lung disease in children.
The Lancet. Microbe
Validated LC-MS/MS Panel for Quantifying 11 Drug-Resistant TB Medications in Small Hair Samples.
Clinical trials (London, England)
Presentation and outcome of suspected sepsis in a high-HIV burden, high antiretroviral coverage setting.
Frontiers in reproductive health
Correlation of Linezolid Hair Concentrations with Plasma Exposure in Patients with Drug-Resistant Tuberculosis.
AIDS patient care and STDs
Prevalence of drug-resistant tuberculosis in Zimbabwe: A health facility-based cross-sectional survey.
Frontiers in reproductive health
Point of care Xpert MTB/RIF versus smear microscopy for tuberculosis diagnosis in southern African primary care clinics: a multicentre economic evaluation.
JCO Oncology Practice
Association of anti-tuberculosis drug concentrations in hair and treatment outcomes in MDR- and XDR-TB.
A Letter about “Prospective Multisite Validation of AI to Detect Tuberculosis and Chest X-Ray Abnormalities”.
Chronic lung disease in adult recurrent tuberculosis survivors in Zimbabwe: a cohort study.
JCI insight
Effect of Xpert MTB/RIF on clinical outcomes in routine care settings: individual patient data meta-analysis.
JCO Oncology Practice
Tuberculosis outbreak investigation using phylodynamic analysis.
Respiratory medicine
Mycobacterium tuberculosis Subculture Results in Loss of Potentially Clinically Relevant Heteroresistance.
AIDS patient care and STDs
Chronic lung disease in HIV-infected children established on antiretroviral therapy.
The Lancet regional health. Southeast Asia
Tuberculosis progression rates in U.S. Immigrants following screening with interferon-gamma release assays.
PLOS global public health
Serial testing for latent tuberculosis using QuantiFERON-TB Gold In-Tube: A Markov model.
The Lancet. Microbe
A multi-analyte panel for non-invasive pharmacokinetic monitoring of second-line anti-tuberculosis drugs.
JCI insight
Xpert(®) MTB/RIF detection of rifampin resistance and time to treatment initiation in Harare, Zimbabwe.
JCI insight
G276(P) Chronic respiratory morbidity among HIV-infected children in Zimbabwe; a comparison of ART naïve and treated cohorts.
Pulmonary circulation
Re-inventing adherence: toward a patient-centered model of care for drug-resistant tuberculosis and HIV.
JCI insight
Moving Beyond Directly Observed Therapy for Tuberculosis.
M_MED-ZSFG-AIDS
Genomic epidemiology of multidrug-resistant Mycobacterium tuberculosis during transcontinental spread.
The Journal of antimicrobial chemotherapy
Analysis of Green Light Committee implementation and acquisition of second-line drug resistance.
The American journal of tropical medicine and hygiene
Empiric tuberculosis treatment in retreatment patients in high HIV/tuberculosis-burden settings.
Essential Strategies for Leveraging AI in the Global HIV Response
Impact of Xpert MTB/RIF on Antiretroviral Therapy-Associated Tuberculosis and Mortality: A Pragmatic Randomized Controlled Trial.
Gates open research
Drug-resistant tuberculosis in high-risk groups, Zimbabwe.
Journal of general internal medicine
Gamma interferon release assays for detection of Mycobacterium tuberculosis infection.
Revista brasileira de epidemiologia = Brazilian journal of epidemiology
Rapid molecular testing for TB to guide respiratory isolation in the U.S.: a cost-benefit analysis.
Research Square
Rifampin monoresistant tuberculosis and HIV comorbidity in California, 1993-2008: a retrospective cohort study.
The Lancet regional health. Southeast Asia
A transcriptional signature for active TB: have we found the needle in the haystack?
M_MED-ZSFG-AIDS
Tuberculosis and HIV co-infection, California, USA, 1993–2008.
Journal of general internal medicine
Microscopic-observation drug-susceptibility assay for the diagnosis of drug-resistant tuberculosis in Harare, Zimbabwe.
Research Square
Impact of isoniazid resistance-conferring mutations on the clinical presentation of isoniazid monoresistant tuberculosis.
Research Square
Interferon-? release assays for active pulmonary tuberculosis diagnosis in adults in low- and middle-income countries: systematic review and meta-analysis.
The Journal of antimicrobial chemotherapy
TB/HIV: an orphan disease?
member
Determinants of multidrug-resistant tuberculosis clusters, California, USA, 2004-2007.
Journal of general internal medicine
Clinical characteristics and treatment outcomes of patients with isoniazid-monoresistant tuberculosis.
The American journal of tropical medicine and hygiene
Leptospirosis-associated severe pulmonary hemorrhagic syndrome, Salvador, Brazil.
Journal of general internal medicine
Endemic malaria in the Peruvian Amazon region of Iquitos.
Public health challenges