Facilitating Accelerated Science and Translation for TB Regimen Development (FAST‑TB) is a global platform that brings together scientists, clinical-trial networks, public-health stakeholders, funders, and industry partners to accelerate the development and uptake of shorter, safer, and more effective tuberculosis (TB) treatment regimens.
Scientifically led by the UCSF Center for Tuberculosis in partnership with CRDF Global, FAST‑TB connects and complements existing TB research networks, national TB programs, regulators, and other stakeholders. The platform creates shared resources to reduce duplication, strengthen decision-making, and speed translation of promising TB regimens into practice. FAST‑TB is supported by the National Institute of Allergy and Infectious Diseases (R24AI200705).
Scientific Leadership
UCSF Principal Investigators Payam Nahid, MD, MPH, and Rada Savic, PhD, provide scientific leadership for FAST‑TB alongside Program Director Christian Lienhardt, MD, PhD, CRDF Global, and an international network of partners.
Four Integrated Tracks
FAST‑TB organizes its work through four interconnected scientific tracks, each co-led by a UCSF investigator and an international partner:
Track | Chairs | Focus |
KITT — Knowledge Integration for TB Treatment | Patrick Phillips, PhD, MS, MA; Gerry Davies, PhD | Creates trusted approaches for knowledge integration, data sharing, trial design, and harmonized clinical endpoints |
GoFAST — Global Forum for biomarkers to Accelerate Simpler TB Treatment | Adithya Cattamanchi, MD, MAS; Daniela M Cirillo, MD, PhD | Advances validation and use of TB treatment biomarkers and drug-resistance assays |
ReLAY — Research to Translate and Yield Evidence into Practice | Priya Shete, MD, MPH; Mario Raviglione, MD | Identifies implementation strategies that help ensure new regimens are feasible, acceptable, equitable, and ready for adoption at scale |
PACE — Population and Cost-Effectiveness | Reza Yaesoubi, PhD; Rein Houben, PhD | Develops models to assess the population impact, cost-effectiveness, and budget implications of new treatment strategies |
Together, the tracks deliver governed knowledge-sharing mechanisms, consensus standards, modeling tools, and implementation resources for the global TB field.