Andrew Kerkhoff, MD, PhD, MS

Assistant Adjunct Professor
Medicine
[email protected]
+1 415 476-1528

Dr. Andew Kerkhoff is a physician-scientist and an Assistant Professor of Medicine in the Division of HIV, Infectious Diseases, and Global Medicine at Zuckerberg San Francisco General Hospital (ZSFG). His research has two main focuses: (1) He has more than a decade of experience evaluating novel tests and strategies to improve the diagnosis of tuberculosis (TB) in sub-Saharan Africa, with a focus on low-cost, point-of-care tools. (2) He also applies implementation science methods to improve individual- and population-level outcomes through the development, implementation, and evaluation of equity-focused, effective, scalable, and sustainable TB, HIV, and COVID-19 care engagement strategies in the United States and Zambia. Dr. Kerkhoff is an Associate Program Director for Curriculum for the UCSF Implementation Science Training Program and also serves as the Director of the UCSF CFAR Implementation Science Interest Group.

UCSF Center for Tuberculosis Leadership & Initiatives:
SMART4TB UCSF Lead, Vaccine Preparedness 

Publications: 

Tuberculosis, mpox, and other infectious complications in persons with HIV

Top Antivir Med

Kerkhoff AD, Zucker J, Havlir DV

Diagnostic yield as an important metric for the evaluation of novel tuberculosis tests – rationale and guidance for future research

Lancet Glob Health

Broger T, Marx FM, Theron G, Marais BJ, Nicol MP, Kerkhoff AD, et al.

Using stated preference methods to facilitate knowledge translation in implementation science.

Implementation science communications

Irie WC, Kerkhoff A, Kim HY, Geng E, Eshun-Wilson I

Placing the values and preferences of people most affected by TB at the center of screening and testing: an approach for reaching the unreached.

BMC Global and Public Health

Andrew D. Kerkhoff, Nora S. West, Maria del Mar Castro, David Branigan, Devasahayam J. Christopher, Claudia M. Denkinger, Nguyen Viet Nhung, Grant Theron, William Worodria, Charles Yu, Monde Muyoyeta, Adithya Cattamanchi

Preferences of people living with HIV for features of tuberculosis preventive treatment regimens - a discrete choice experiment.

medRxiv : the preprint server for health sciences

Aschmann HE, Musinguzi A, Kadota JL, Namale C, Kakeeto J, Nakimuli J, Akello L, Welishe F, Nakitende A, Berger C, Dowdy DW, Cattamanchi A, Semitala FC, Kerkhoff AD

Improving measurement of tuberculosis care cascades to enhance people-centred care.

The Lancet. Infectious diseases

Faust L, Naidoo P, Caceres-Cardenas G, Ugarte-Gil C, Muyoyeta M, Kerkhoff AD, Nagarajan K, Satyanarayana S, Rakotosamimanana N, Grandjean Lapierre S, Adejumo OA, Kuye J, Oga-Omenka C, Pai M, Subbaraman R

Strategies to increase childhood tuberculosis case detection at the primary health care level: Lessons from an active case finding study in Zambia.

PloS one

Kagujje M, Nyangu S, Maimbolwa MM, Shuma B, Mutti L, Somwe P, Sanjase N, Chungu C, Kerkhoff AD, Muyoyeta M

CROI 2023: Tuberculosis and Infectious Complications in Persons With HIV.

Topics in antiviral medicine

Kerkhoff AD, Havlir DV

A mixed methods study on men's and women's tuberculosis care journeys in Lusaka, Zambia-Implications for gender-tailored tuberculosis health promotion and case finding strategies.

PLOS Global Public Health

Kerkhoff AD, Mwamba C, Pry JM, Kagujje M, Nyangu S, Mateyo K, Sanjase N, Chilukutu L, Christopoulos KA, Muyoyeta M, Sharma A

Clinical utility of WHO-recommended screening tools and development and validation of novel clinical prediction models for pulmonary tuberculosis screening among outpatients living with HIV: an individual participant data meta-analysis.

European respiratory review : an official journal of the European Respiratory Society

Dhana A, Gupta RK, Hamada Y, Kengne AP, Kerkhoff AD, Yoon C, Cattamanchi A, Reeve BWP, Theron G, Ndlangalavu G, Wood R, Drain PK, Calderwood CJ, Noursadeghi M, Boyles T, Meintjes G, Maartens G, Barr DA

Diagnostic yield of urine lipoarabinomannan and sputum tuberculosis tests in people living with HIV: a systematic review and meta-analysis of individual participant data.

The Lancet. Global health

Broger T, Koeppel L, Huerga H, Miller P, Gupta-Wright A, Blanc FX, Esmail A, Reeve BWP, Floridia M, Kerkhoff AD, Ciccacci F, Kasaro MP, Thit SS, Bastard M, Ferlazzo G, Yoon C, Van Hoving DJ, Sossen B, García JI, Cummings MJ, Wake RM, Hanson J, Cattamanchi A, Meintjes G, Maartens G, Wood R, Theron G, Dheda K, Olaru ID, Denkinger CM, TBYield Study Consortium

The performance of computer-aided detection digital chest X-ray reading technologies for triage of active Tuberculosis among persons with a history of previous Tuberculosis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Kagujje M, Kerkhoff AD, Nteeni M, Dunn I, Mateyo K, Muyoyeta M

COVID-19 Symptoms and Duration of Rapid Antigen Test Positivity at a Community Testing and Surveillance Site During Pre-Delta, Delta, and Omicron BA.1 Periods.

JAMA network open

Marquez C, Kerkhoff AD, Schrom J, Rojas S, Black D, Mitchell A, Wang CY, Pilarowski G, Ribeiro S, Jones D, Payan J, Manganelli S, Rojas S, Lemus J, Jain V, Chamie G, Tulier-Laiwa V, Petersen M, DeRisi J, Havlir DV

CROI 2022: tuberculosis and infectious complications in persons With HIV.

Topics in antiviral medicine

Kerkhoff AD, Havlir DV

Undernotification and underreporting of tuberculosis in Zambia: a national data quality assessment.

BMC health services research

Lungu PS, Kabaso ME, Mihova R, Silumesii A, Chisenga T, Kasapo C, Mwaba I, Kerkhoff AD, Muyoyeta M, Chimzizi R, Malama K

Patient Preferences for Strategies to Improve Tuberculosis Diagnostic Services in Zambia.

JAMA network open

Kerkhoff AD, Chilukutu L, Nyangu S, Kagujje M, Mateyo K, Sanjase N, Eshun-Wilson I, Geng EH, Havlir DV, Muyoyeta M

Heterogeneous preferences for care engagement among people with HIV experiencing homelessness or unstable housing during the COVID-19 pandemic.

Journal of acquired immune deficiency syndromes (1999)

Imbert E, Hickey MD, Del Rosario JB, Conte M, Kerkoff AD, Clemenzi-Allen A, Riley ED, Havlir DV, Gandhi M

Diagnostic accuracy of WHO screening criteria to guide lateral-flow lipoarabinomannan testing among HIV-positive inpatients: a systematic review and individual participant data meta-analysis.

The Journal of infection

Dhana A, Hamada Y, Kengne AP, Kerkhoff AD, Broger T, Denkinger CM, Rangaka MX, Gupta-Wright A, Fielding K, Wood R, Huerga H, Rucker SCM, Bjerrum S, Johansen IS, Thit SS, Kyi MM, Hanson J, Barr DA, Meintjes G, Maartens G

Integrating Rapid Diabetes Screening Into a Latinx Focused Community-Based Low-Barrier COVID-19 Testing Program.

JAMA network open

Kerkhoff AD, Rojas S, Black D, Ribeiro S, Rojas S, Valencia R, Lemus J, Payan J, Schrom J, Jones D, Manganelli S, Bandi S, Chamie G, Tulier-Laiwa V, Petersen M, Havlir D, Marquez C

Evaluation of kidney function among people living with HIV initiating antiretroviral therapy in Zambia.

PLOS Global Public Health

Jake M. Pry, Michael J. Vinikoor, Carolyn Bolton Moore, Monika Roy, Aaloke Mody, Izukanji Sikazwe, Anjali Sharma, Belinda Chihota, Miquel Duran-Frigola, Harriet Daultrey, Jacob Mutale, Andrew D. Kerkhoff, Elvin H. Geng, Brad H. Pollock, Jaime H. Vera

Tuberculosis screening among HIV-positive inpatients: a systematic review and individual participant data meta-analysis.

The lancet. HIV

Dhana A, Hamada Y, Kengne AP, Kerkhoff AD, Rangaka MX, Kredo T, Baddeley A, Miller C, Gupta-Wright A, Fielding K, Wood R, Huerga H, Rücker SCM, Heidebrecht C, Wilson D, Bjerrum S, Johansen IS, Thit SS, Kyi MM, Hanson J, Barr DA, Meintjes G, Maartens G

Prevalence and interpretation of Xpert® Ultra trace results among presumptive TB patients.

Public health action

Chilukutu L, Mwanza W, Kerkhoff AD, Somwe P, Kagujje M, Muyoyeta M

Addressing health disparities through implementation science-a need to integrate an equity lens from the outset.

Implementation science : IS

Kerkhoff AD, Farrand E, Marquez C, Cattamanchi A, Handley MA

Interrupted time-series analysis of active case-finding for tuberculosis during the COVID-19 pandemic, Zambia.

Bulletin of the World Health Organization

Lungu PS, Kerkhoff AD, Muyoyeta M, Kasapo CC, Nyangu S, Kagujje M, Chimzizi R, Nyimbili S, Khunga M, Kasese-Chanda N, Musonda V, Tambatamba B, Kombe CM, Sakulanda C, Sampa K, Silumesii A, Malama K

Mitigating the effects of COVID-19 on HIV treatment and care in Lusaka, Zambia: a before-after cohort study using mixed effects regression.

BMJ global health

Pry JM, Sikombe K, Mody A, Iyer S, Mutale J, Vlahakis N, Savory T, Wa Mwanza M, Mweebo K, Mwila A, Mwale C, Mukumbwa-Mwenechanya M, Kerkhoff AD, Sikazwe I, Bolton Moore C, Mwamba D, Geng EH, Herce ME

Tuberculosis screening among ambulatory people living with HIV: a systematic review and individual participant data meta-analysis.

The Lancet. Infectious diseases

Dhana A, Hamada Y, Kengne AP, Kerkhoff AD, Rangaka MX, Kredo T, Baddeley A, Miller C, Singh S, Hanifa Y, Grant AD, Fielding K, Affolabi D, Merle CS, Wachinou AP, Yoon C, Cattamanchi A, Hoffmann CJ, Martinson N, Mbu ET, Sander MS, Balcha TT, Skogmar S, Reeve BWP, Theron G, Ndlangalavu G, Modi S, Cavanaugh J, Swindells S, Chaisson RE, Ahmad Khan F, Howard AA, Wood R, Thit SS, Kyi MM, Hanson J, Drain PK, Shapiro AE, Kufa T, Churchyard G, Nguyen DT, Graviss EA, Bjerrum S, Johansen IS, Gersh JK, Horne DJ, LaCourse SM, Al-Darraji HAA, Kamarulzaman A, Kempker RR, Tukvadze N, Barr DA, Meintjes G, Maartens G

Cost-effectiveness of a Novel Lipoarabinomannan Test for Tuberculosis in Patients With Human Immunodeficiency Virus.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Reddy KP, Denkinger CM, Broger T, McCann NC, Gupta-Wright A, Kerkhoff AD, Pei PP, Shebl FM, Fielding KL, Nicol MP, Horsburgh CR, Meintjes G, Freedberg KA, Wood R, Walensky RP

Tuberculosis and anemia-cause or effect?

Environmental health and preventive medicine

Cobelens F, Kerkhoff AD

A multi-component, community-based strategy to facilitate COVID-19 vaccine uptake among Latinx populations: From theory to practice.

PloS one

Marquez C, Kerkhoff AD, Naso J, Contreras MG, Castellanos Diaz E, Rojas S, Peng J, Rubio L, Jones D, Jacobo J, Rojas S, Gonzalez R, Fuchs JD, Black D, Ribeiro S, Nossokoff J, Tulier-Laiwa V, Martinez J, Chamie G, Pilarowski G, DeRisi J, Petersen M, Havlir DV

Derivation and external validation of a risk score for predicting HIV-associated tuberculosis to support case finding and preventive therapy scale-up: A cohort study.

PLoS medicine

Auld AF, Kerkhoff AD, Hanifa Y, Wood R, Charalambous S, Liu Y, Agizew T, Mathoma A, Boyd R, Date A, Shiraishi RW, Bicego G, Mathebula-Modongo U, Alexander H, Serumola C, Rankgoane-Pono G, Pono P, Finlay A, Shepherd JC, Ellerbrock TV, Grant AD, Fielding K

Validating novel diagnostic assays for tuberculosis in the context of existing tools.

The Lancet. Global health

Kerkhoff AD, Cattamanchi A, Muyoyeta M, Denkinger CM, Dowdy DW

Pathways to care and preferences for improving tuberculosis services among tuberculosis patients in Zambia: A discrete choice experiment.

PloS one

Kerkhoff AD, Kagujje M, Nyangu S, Mateyo K, Sanjase N, Chilukutu L, Eshun-Wilson I, Geng EH, Havlir DV, Muyoyeta M

Tuberculosis care cascade in Zambia - identifying the gaps in order to improve outcomes: a population-based analysis.

BMJ open

Lungu P, Kerkhoff AD, Kasapo CC, Mzyece J, Nyimbili S, Chimzizi R, Silumesii A, Kagujje M, Subbaraman R, Muyoyeta M, Malama K

SARS-CoV-2 Community Transmission disproportionately affects Latinx population during Shelter-in-Place in San Francisco.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Chamie G, Marquez C, Crawford E, Peng J, Petersen M, Schwab D, Schwab J, Martinez J, Es DJ, Black D, Gandhi M, Kerkhoff AD, Jain V, Sergi F, Jacobo J, Rojas S, Tulier-Laiwa V, Gallardo-Brown T, Appa A, Chiu C, Rodgers M, Hackett J, Kistler A, Hao S, Kamm J, Dynerman D, Batson J, Greenhouse B, DeRisi J, Havlir DV

Diagnosed with TB in the era of COVID-19: patient perspectives in Zambia.

Public health action

Mwamba C, Kerkhoff AD, Kagujje M, Lungu P, Muyoyeta M, Sharma A

"SILVAMP TB LAM" Rapid Urine Tuberculosis Test Predicts Mortality in Patients Hospitalized With Human Immunodeficiency Virus in South Africa.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Sossen B, Broger T, Kerkhoff AD, Schutz C, Trollip A, Moreau E, Schumacher SG, Burton R, Ward A, Wilkinson RJ, Barr DA, Nicol MP, Denkinger CM, Meintjes G

Evaluation of a novel community-based COVID-19 'Test-to-Care' model for low-income populations.

PloS one

Kerkhoff AD, Sachdev D, Mizany S, Rojas S, Gandhi M, Peng J, Black D, Jones D, Rojas S, Jacobo J, Tulier-Laiwa V, Petersen M, Martinez J, Chamie G, Havlir DV, Marquez C

Clinical Utility of Universal Broad-Range Polymerase Chain Reaction Amplicon Sequencing for Pathogen Identification: A Retrospective Cohort Study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Kerkhoff AD, Rutishauser RL, Miller S, Babik JM

Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: A retrospective cohort study of patients with and without COVID-19.

EClinicalMedicine

Shah SJ, Barish PN, Prasad PA, Kistler A, Neff N, Kamm J, Li LM, Chiu CY, Babik JM, Fang MC, Kangelaris KN, Langelier C, Abe-Jones Y, Alipanah N, Alvarez FN, Botvinnik OB, Castaneda G

Determine TB-LAM point-of-care tuberculosis assay predicts poor outcomes in outpatients during their first year of antiretroviral therapy in South Africa.

BMC infectious diseases

Kerkhoff AD, Longley N, Kelly N, Cross A, Vogt M, Wood R, Hermans S, Lawn SD, Harrison TS

Virtual CROI 2020: Tuberculosis and Coinfections In HIV Infection.

Topics in antiviral medicine

Kerkhoff AD, Havlir DV

Mortality estimates by age and sex among persons living with HIV after ART initiation in Zambia using electronic medical records supplemented with tracing a sample of lost patients: A cohort study.

PLoS medicine

Kerkhoff AD, Sikombe K, Eshun-Wilson I, Sikazwe I, Glidden DV, Pry JM, Somwe P, Beres LK, Simbeza S, Mwamba C, Bukankala C, Hantuba C, Moore CB, Holmes CB, Padian N, Geng EH

Diagnostic accuracy of a novel tuberculosis point-of-care urine lipoarabinomannan assay for people living with HIV: A meta-analysis of individual in- and outpatient data.

PLoS medicine

Broger T, Nicol MP, Székely R, Bjerrum S, Sossen B, Schutz C, Opintan JA, Johansen IS, Mitarai S, Chikamatsu K, Kerkhoff AD, Macé A, Ongarello S, Meintjes G, Denkinger CM, Schumacher SG

Response to: Is Burnout Infectious? Understanding Drivers of Burnout and Job Satisfaction Among Academic Infectious Diseases Physicians.

Open forum infectious diseases

Budak JZ, Brickman CE, Abdoler EA, Wallender EK, Mulliken JS, Kerkhoff AD, Lampiris H, Babik JM, Koss CA, Schwartz BS

Community-wide Screening for Tuberculosis.

The New England journal of medicine

Kerkhoff AD, Muyoyeta M, Cattamanchi A

Mycobacterium tuberculosis bloodstream infection prevalence, diagnosis, and mortality risk in seriously ill adults with HIV: a systematic review and meta-analysis of individual patient data.

The Lancet. Infectious diseases

Barr DA, Lewis JM, Feasey N, Schutz C, Kerkhoff AD, Jacob ST, Andrews B, Kelly P, Lakhi S, Muchemwa L, Bacha HA, Hadad DJ, Bedell R, van Lettow M, Zachariah R, Crump JA, Alland D, Corbett EL, Gopinath K, Singh S, Griesel R, Maartens G, Mendelson M, Ward AM, Parry CM, Talbot EA, Munseri P, Dorman SE, Martinson N, Shah M, Cain K, Heilig CM, Varma JK, von Gottberg A, Sacks L, Wilson D, Squire SB, Lalloo DG, Davies G, Meintjes G

Diagnostic sensitivity of SILVAMP TB-LAM (FujiLAM) point-of-care urine assay for extra-pulmonary tuberculosis in people living with HIV.

The European respiratory journal

Kerkhoff AD, Sossen B, Schutz C, Reipold EI, Trollip A, Moreau E, Schumacher SG, Burton R, Ward A, Nicol MP, Meintjes G, Denkinger CM, Broger T

Tuberculosis test results using fresh versus biobanked urine samples with FujiLAM.

The Lancet. Infectious diseases

Broger T, Muyoyeta M, Kerkhoff AD, Denkinger CM, Moreau E

HIV and Tuberculosis: A Formidable Alliance

Diagnosis of HIV-associated tuberculosis

Kerkhoff AD, Cattamanchi A

False rifampicin resistant results using Xpert MTB/RIF on urine samples in hospitalised HIV-infected patients.

Southern African journal of HIV medicine

Schutz C, Ward A, Burton R, Nicol MP, Blumenthal L, Meintjes G, Kerkhoff AD

Novel lipoarabinomannan point-of-care tuberculosis test for people with HIV: a diagnostic accuracy study.

The Lancet. Infectious diseases

Broger T, Sossen B, du Toit E, Kerkhoff AD, Schutz C, Ivanova Reipold E, Ward A, Barr DA, Macé A, Trollip A, Burton R, Ongarello S, Pinter A, Lowary TL, Boehme C, Nicol MP, Meintjes G, Denkinger CM

HIV-Associated Mycobacterium tuberculosis Bloodstream Infection Is Underdiagnosed by Single Blood Culture.

Journal of clinical microbiology

Barr DA, Kerkhoff AD, Schutz C, Ward AM, Davies GR, Wilkinson RJ, Meintjes G

Urinary Lipoarabinomannan Detection and Disseminated Nontuberculous Mycobacterial Disease.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Gupta-Wright A, Kerkhoff AD, Meintjes G, Corbett EL

Severe piperacillin-tazobactam-induced hemolysis in a cystic fibrosis patient.

Clinical case reports

Kerkhoff AD, Patrick L, Cornett P, Kleinhenz ME, Brondfield S

Anaemia in patients with HIV-associated TB: relative contributions of anaemia of chronic disease and iron deficiency.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

Kerkhoff AD, Meintjes G, Opie J, Vogt M, Jhilmeet N, Wood R, Lawn SD

HIV-Related Medical Admissions to a South African District Hospital Remain Frequent Despite Effective Antiretroviral Therapy Scale-Up.

Medicine

Meintjes G, Kerkhoff AD, Burton R, Schutz C, Boulle A, Van Wyk G, Blumenthal L, Nicol MP, Lawn SD

Rapid diagnosis of TB in HIV-positive in-patients with M. tuberculosis bacteraemia in sub-Saharan Africa.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

Lawn SD, Kerkhoff AD

Underestimation of the True Specificity of the Urine Lipoarabinomannan Point-of-Care Diagnostic Assay for HIV-Associated Tuberculosis.

Journal of acquired immune deficiency syndromes (1999)

Lawn SD, Kerkhoff AD, Nicol MP, Meintjes G

Iron replacement therapy and anemia associated with chronic infectious diseases in sub-Saharan Africa.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Kerkhoff AD, Lawn SD

A Rare Complication of Cytomegalovirus Infection

Infect Dis Clin Pract

Kerkhoff AD, Reyes JA, Robert AD, Simon GL.

In reply to 'C-reactive protein and tuberculosis screening: a new trick for an old dog?'.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

Lawn SD, Kerkhoff AD, Wood R

Diagnostic and prognostic value of serum C-reactive protein for screening for HIV-associated tuberculosis.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

Lawn SD, Kerkhoff AD, Vogt M, Wood R

Serum C-reactive protein measurement for ruling out HIV-associated tuberculosis.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

Lawn SD, Kerkhoff AD

Systematic review of TST responses in people living with HIV in under-resourced settings: implications for isoniazid preventive therapy.

PloS one

Kerkhoff AD, Kranzer K, Samandari T, Nakiyingi-Miiro J, Whalen CC, Harries AD, Lawn SD

Diagnostic yield of tuberculosis using sputum induction in HIV-positive patients before antiretroviral therapy.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

Lawn SD, Kerkhoff AD, Pahlana P, Vogt M, Wood R

Reply to Theron et al

Clin Infect Dis

Lawn SD, Kerkhoff AD, Wood R

Location of Xpert® MTB/RIF in centralised laboratories in South Africa undermines potential impact.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

Lawn SD, Kerkhoff AD, Wood R

Characteristics and early outcomes of patients with Xpert MTB/RIF-negative pulmonary tuberculosis diagnosed during screening before antiretroviral therapy.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Lawn SD, Kerkhoff AD, Vogt M, Ghebrekristos Y, Whitelaw A, Wood R

Comparison of transabdominal ultrasound and electromagnetic transponders for prostate localization.

Journal of applied clinical medical physics

Foster RD, Solberg TD, Li HS, Kerkhoff A, Enke CA, Willoughby TR, Kupelian PA