Babak Javid, MB, PhD

Co-Director, UCSF Center for Tuberculosis

Co-Director, UC TRAC Basic Science Core

Professor

Medicine

Dr. Javid is a physician-scientist, Wellcome Trust Investigator and Associate Professor in the Division of Experimental Medicine at UCSF. His research focuses on fundamental mycobacterial pathophysiology, regulation of adaptive protein synthesis, molecular mechanisms of antibiotic tolerance and human humoral immunity to tuberculosis. He went to medical school at the University of Cambridge, and after residency in general (internal) medicine returned to Cambridge to study for a PhD in immunobiology as an MRC training fellow. Following fellowship in infectious diseases, Dr. Javid went to Boston as an MRC Clinician Scientist Fellow to work on mycobacterial genetics with Eric Rubin at Harvard. He started his independent research career in 2011 at Tsinghua University in Beijing and joined the faculty at UCSF in July 2020.

Javid Lab: https://experimentalmedicine.ucsf.edu/laboratories/javid-lab

UCSF Center for Tuberculosis Leadership & Initiatives:
UCSF Center for Tuberculosis Associate Director
UC TRAC Basic Science Core Co-Director
Bay Area TB Science (BATS) Symposium Chair
TB RAMP Mentor / Executive Committee Member

Publications:

Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates from a longitudinal study.

eLife

Vijay S, Bao NLH, Vinh DN, Nhat LTH, Thu DDA, Quang NL, Trieu LPT, Nhung HN, Ha VTN, Thai PVK, Ha DTM, Lan NH, Caws M, Thwaites GE, Javid B, Thuong NT

A quest for novel antimicrobial targets: Inhibition of Asp-tRNAAsn/Glu-tRNAGln amidotransferase (GatCAB) by synthetic analogs of aminoacyl-adenosine in vitro and live bacteria.

Bioorganic chemistry

Sangsuwan W, Taweesablamlert A, Boonkerd A, Isarangkool Na Ayutthaya C, Yoo S, Javid B, Faikhruea K, Vilaivan T, Aonbangkhen C, Chuawong P

Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates: an in-vitro longitudinal study.

bioRxiv : the preprint server for biology

Vijay S, Bao NLH, Vinh DN, Nhat LTH, Thu DDA, Quang NL, Trieu LPT, Nhung HN, Ha VTN, Thai PVK, Ha DTM, Lan NH, Caws M, Thwaites GE, Javid B, Thuong NTT

A teenage girl with altered mental status and paraparesis.

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases

Miyakawa R, Louie J, Keh C, Chen L, Javid B, Ernst JD, Goswami N, Chow FC

Mechanical morphotype switching as an adaptive response in mycobacteria.

Science advances

Eskandarian HA, Chen YX, Toniolo C, Belardinelli JM, Palcekova Z, Hom L, Ashby PD, Fantner GE, Jackson M, McKinney JD, Javid B

Author Correction: An anti-LpqH human monoclonal antibody from an asymptomatic individual mediates protection against Mycobacterium tuberculosis.

NPJ vaccines

Krishnananthasivam S, Li H, Bouzeyen R, Shunmuganathan B, Purushotorman K, Liao X, Du F, Friis CGK, Crawshay-Williams F, Boon LH, Xinlei Q, Chan CEZ, Sobota R, Kozma M, Barcelli V, Wang G, Huang H, Floto A, Bifani P, Javid B, MacAry PA

An anti-LpqH human monoclonal antibody from an asymptomatic individual mediates protection against Mycobacterium tuberculosis.

NPJ vaccines

Krishnananthasivam S, Li H, Bouzeyen R, Shunmuganathan B, Purushotorman K, Liao X, Du F, Friis CGK, Crawshay-Williams F, Boon LH, Xinlei Q, Chan CEZ, Sobota R, Kozma M, Jo VB, Wang G, Huang H, Floto A, Bifani P, Javid B, MacAry PA

Navigating a Path to Rifampicin Resistance in Tuberculosis.

mBio

Agarwal S, Javid B

Therapeutic Vaccines for Tuberculosis: An Overview.

Frontiers in immunology

Bouzeyen R, Javid B

The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: A genotypic analysis.

The Lancet. Microbe

Walker TM, Miotto P, K?ser CU, Fowler PW, Knaggs J, Iqbal Z, Hunt M, Chindelevitch L, Farhat M, Cirillo DM, Comas I, Posey J, Omar SV, Peto TE, Suresh A, Uplekar S, Laurent S, Colman RE, Nathanson CM, Zignol M, Walker AS, CRyPTIC Consortium, Seq&Treat Consortium, Crook DW, Ismail N, Rodwell TC

Harnessing Twitter data to survey public attention and attitudes towards COVID-19 vaccines in the UK.

Scientific reports

Fazel S, Zhang L, Javid B, Brikell I, Chang Z

100 years of antibody solitude in TB.

Nature immunology

Divangahi M, Javid B, Kaufmann E

Clinically Relevant Mutations of Mycobacterial GatCAB Inform Regulation of Translational Fidelity.

mBio

Li YY, Cai RJ, Yang JY, Hendrickson TL, Xiang Y, Javid B

Should masks be worn outdoors?

BMJ (Clinical research ed.)

Direct and indirect evidence of efficacy and safety of rapid exercise tests for exertional desaturation in Covid-19: a rapid systematic review.

Systematic reviews

Kalin A, Javid B, Knight M, Inada-Kim M, Greenhalgh T

Most-probable number based minimum duration of killing assay for determining the spectrum of rifampicin susceptibility in clinical M. tuberculosis isolates.

Antimicrobial agents and chemotherapy

Vijay S, Nhung HN, Bao NLH, Thu DDA, Trieu LPT, Phu NH, Thwaites GE, Javid B, Thuong NTT

Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis.

Nature communications

Watson A, Li H, Ma B, Weiss R, Bendayan D, Abramovitz L, Ben-Shalom N, Mor M, Pinko E, Bar Oz M, Wang Z, Du F, Lu Y, Rybniker J, Dahan R, Huang H, Barkan D, Xiang Y, Javid B, Freund NT

Managing outbreaks of highly contagious diseases in prisons: a systematic review.

BMJ global health

Beaudry G, Zhong S, Whiting D, Javid B, Frater J, Fazel S

Forward Genetics Reveals a gatC-gatA Fusion Polypeptide Causes Mistranslation and Rifampicin Tolerance in Mycobacterium smegmatis.

Frontiers in microbiology

Cai RJ, Su HW, Li YY, Javid B

Selective translation by alternative bacterial ribosomes.

Proceedings of the National Academy of Sciences of the United States of America

Chen YX, Xu ZY, Ge X, Sanyal S, Lu ZJ, Javid B

Premature termination codon readthrough in Drosophila varies in a developmental and tissue-specific manner.

Scientific reports

Chen Y, Sun T, Bi Z, Ni JQ, Pastor-Pareja JC, Javid B

Clinically relevant mutations in mycobacterial LepA cause rifampicin-specific phenotypic resistance.

Scientific reports

Wang BW, Zhu JH, Javid B

Covid-19: should the public wear face masks?

BMJ (Clinical research ed.)

Javid B, Weekes MP, Matheson NJ

HspX promotes the polar localization of mycobacterial protein aggregates.

Scientific reports

Zhang YW, Zhu JH, Wang ZQ, Wu Y, Meng X, Zheng X, Javid B

Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in Mycobacterium tuberculosis.

ACS infectious diseases

Wu J, Mu R, Sun M, Zhao N, Pan M, Li H, Dong Y, Sun Z, Bai J, Hu M, Nathan CF, Javid B, Liu G

Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems.

Journal of visualized experiments : JoVE

Chen YX, Pan M, Chen YM, Javid B

Rifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpoB transcription.

Nature communications

Zhu JH, Wang BW, Pan M, Zeng YN, Rego H, Javid B

More than merely drug resistance.

Nature microbiology

Chen YX, Javid B

Antibodies and tuberculosis: finally coming of age?

Nature reviews. Immunology

Li H, Javid B

Transmission of toxigenic Corynebacterium diphtheriae by a fully immunised resident returning from a visit to West Africa, United Kingdom, 2017.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

Edwards D, Kent D, Lester C, Brown CS, Murphy ME, Brown NM, Sule O, Itani A, Chand M, Trindall A, Pearson C, Roddick I, Fry NK, Hoffmann J, Iyanger N, Kemp L, White J, Javid B, Ramsay ID, Zenner D, Ahmed A, Amirthalingam G, Salimee S, Litt D, Reacher M

Kasugamycin potentiates rifampicin and limits emergence of resistance in Mycobacterium tuberculosis by specifically decreasing mycobacterial mistranslation.

eLife

Chaudhuri S, Li L, Zimmerman M, Chen Y, Chen YX, Toosky MN, Gardner M, Pan M, Li YY, Kawaji Q, Zhu JH, Su HW, Martinot AJ, Rubin EJ, Dartois VA, Javid B

Latently and uninfected healthcare workers exposed to TB make protective antibodies against Mycobacterium tuberculosis.

Proceedings of the National Academy of Sciences of the United States of America

Li H, Wang XX, Wang B, Fu L, Liu G, Lu Y, Cao M, Huang H, Javid B

Over-Expression of the Mycobacterial Trehalose-Phosphate Phosphatase OtsB2 Results in a Defect in Macrophage Phagocytosis Associated with Increased Mycobacterial-Macrophage Adhesion.

Frontiers in microbiology

Li H, Wu M, Shi Y, Javid B

The essential mycobacterial amidotransferase GatCAB is a modulator of specific translational fidelity.

Nature microbiology

Su HW, Zhu JH, Li H, Cai RJ, Ealand C, Wang X, Chen YX, Kayani MU, Zhu TF, Moradigaravand D, Huang H, Kana BD, Javid B

Plasma Membrane Profiling Reveals Upregulation of ABCA1 by Infected Macrophages Leading to Restriction of Mycobacterial Growth.

Frontiers in microbiology

Long J, Basu Roy R, Zhang YJ, Antrobus R, Du Y, Smith DL, Weekes MP, Javid B

dfrA thyA Double Deletion in para-Aminosalicylic Acid-Resistant Mycobacterium tuberculosis Beijing Strains.

Antimicrobial agents and chemotherapy

Moradigaravand D, Grandjean L, Martinez E, Li H, Zheng J, Coronel J, Moore D, Török ME, Sintchenko V, Huang H, Javid B, Parkhill J, Peacock SJ, Köser CU

Whole-genome sequencing for the diagnosis of drug-resistant tuberculosis.

The Lancet. Infectious diseases

Javid B, Török ME

Translational misreading in Mycobacterium smegmatis increases in stationary phase.

Tuberculosis (Edinburgh, Scotland)

Leng T, Pan M, Xu X, Javid B

Uniform and amorphous rifampicin microspheres obtained by freezing induced LLPS during lyophilization.

International journal of pharmaceutics

Liu C, Kong C, Wu G, Zhu J, Javid B, Qian F

Transmitted Extended-Spectrum Extensively Drug-Resistant Tuberculosis in Beijing, China, with Discordant Whole-Genome Sequencing Analysis Results.

Journal of clinical microbiology

Li H, Kayani Mu, Gu Y, Wang X, Zhu T, Duan H, Ma Y, Huang H, Javid B

Human H+ATPase a4 subunit mutations causing renal tubular acidosis reveal a role for interaction with phosphofructokinase-1.

American journal of physiology. Renal physiology

Su Y, Blake-Palmer KG, Sorrell S, Javid B, Bowers K, Zhou A, Chang SH, Qamar S, Karet FE

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Babak Javid, MB, PhD