Babak Javid, MB, PhD

Associate Director, Bench Science, UCSF Center for Tuberculosis
Medicine

Dr. Javid is a physician-scientist, Wellcome Trust Investigator and Associate Professor in the Division of Experimental Medicine at UCSF.  His research focuses on fundamental mycobacterial pathophysiology, regulation of adaptive protein synthesis, molecular mechanisms of antibiotic tolerance and human humoral immunity to tuberculosis.  He went to medical school at the University of Cambridge, and after residency in general (internal) medicine returned to Cambridge to study for a PhD in immunobiology as an MRC training fellow. Following fellowship in infectious diseases, Dr. Javid went to Boston as an MRC Clinician Scientist Fellow to work on mycobacterial genetics with Eric Rubin at Harvard.  He started his independent research career in 2011 at Tsinghua University in Beijing and joined the faculty at UCSF in July 2020.

Javid Lab: https://experimentalmedicine.ucsf.edu/laboratories/javid-lab

 

Publications: 

100 years of antibody solitude in TB.

Nature immunology

Divangahi M, Javid B, Kaufmann E

Should masks be worn outdoors?

BMJ (Clinical research ed.)

Most-probable number based minimum duration of killing assay for determining the spectrum of rifampicin susceptibility in clinical M. tuberculosis isolates.

Antimicrobial agents and chemotherapy

Vijay S, Nhung HN, Bao NLH, Thu DDA, Trieu LPT, Phu NH, Thwaites GE, Javid B, Thuong NTT

Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis.

Nature communications

Watson A, Li H, Ma B, Weiss R, Bendayan D, Abramovitz L, Ben-Shalom N, Mor M, Pinko E, Bar Oz M, Wang Z, Du F, Lu Y, Rybniker J, Dahan R, Huang H, Barkan D, Xiang Y, Javid B, Freund NT

Managing outbreaks of highly contagious diseases in prisons: a systematic review.

BMJ global health

Beaudry G, Zhong S, Whiting D, Javid B, Frater J, Fazel S

Selective translation by alternative bacterial ribosomes.

Proceedings of the National Academy of Sciences of the United States of America

Chen YX, Xu ZY, Ge X, Sanyal S, Lu ZJ, Javid B

Premature termination codon readthrough in Drosophila varies in a developmental and tissue-specific manner.

Scientific reports

Chen Y, Sun T, Bi Z, Ni JQ, Pastor-Pareja JC, Javid B

Covid-19: should the public wear face masks?

BMJ (Clinical research ed.)

Javid B, Weekes MP, Matheson NJ

HspX promotes the polar localization of mycobacterial protein aggregates.

Scientific reports

Zhang YW, Zhu JH, Wang ZQ, Wu Y, Meng X, Zheng X, Javid B

Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in Mycobacterium tuberculosis.

ACS infectious diseases

Wu J, Mu R, Sun M, Zhao N, Pan M, Li H, Dong Y, Sun Z, Bai J, Hu M, Nathan CF, Javid B, Liu G

Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems.

Journal of visualized experiments : JoVE

Chen YX, Pan M, Chen YM, Javid B

Rifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpoB transcription.

Nature communications

Zhu JH, Wang BW, Pan M, Zeng YN, Rego H, Javid B

More than merely drug resistance.

Nature microbiology

Chen YX, Javid B

Antibodies and tuberculosis: finally coming of age?

Nature reviews. Immunology

Li H, Javid B

Transmission of toxigenic Corynebacterium diphtheriae by a fully immunised resident returning from a visit to West Africa, United Kingdom, 2017.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

Edwards D, Kent D, Lester C, Brown CS, Murphy ME, Brown NM, Sule O, Itani A, Chand M, Trindall A, Pearson C, Roddick I, Fry NK, Hoffmann J, Iyanger N, Kemp L, White J, Javid B, Ramsay ID, Zenner D, Ahmed A, Amirthalingam G, Salimee S, Litt D, Reacher M

Kasugamycin potentiates rifampicin and limits emergence of resistance in Mycobacterium tuberculosis by specifically decreasing mycobacterial mistranslation.

eLife

Chaudhuri S, Li L, Zimmerman M, Chen Y, Chen YX, Toosky MN, Gardner M, Pan M, Li YY, Kawaji Q, Zhu JH, Su HW, Martinot AJ, Rubin EJ, Dartois VA, Javid B

Latently and uninfected healthcare workers exposed to TB make protective antibodies against Mycobacterium tuberculosis.

Proceedings of the National Academy of Sciences of the United States of America

Li H, Wang XX, Wang B, Fu L, Liu G, Lu Y, Cao M, Huang H, Javid B

The essential mycobacterial amidotransferase GatCAB is a modulator of specific translational fidelity.

Nature microbiology

Su HW, Zhu JH, Li H, Cai RJ, Ealand C, Wang X, Chen YX, Kayani MU, Zhu TF, Moradigaravand D, Huang H, Kana BD, Javid B

Plasma Membrane Profiling Reveals Upregulation of ABCA1 by Infected Macrophages Leading to Restriction of Mycobacterial Growth.

Frontiers in microbiology

Long J, Basu Roy R, Zhang YJ, Antrobus R, Du Y, Smith DL, Weekes MP, Javid B

dfrA thyA Double Deletion in para-Aminosalicylic Acid-Resistant Mycobacterium tuberculosis Beijing Strains.

Antimicrobial agents and chemotherapy

Moradigaravand D, Grandjean L, Martinez E, Li H, Zheng J, Coronel J, Moore D, Török ME, Sintchenko V, Huang H, Javid B, Parkhill J, Peacock SJ, Köser CU

Whole-genome sequencing for the diagnosis of drug-resistant tuberculosis.

The Lancet. Infectious diseases

Javid B, Török ME

Translational misreading in Mycobacterium smegmatis increases in stationary phase.

Tuberculosis (Edinburgh, Scotland)

Leng T, Pan M, Xu X, Javid B

Uniform and amorphous rifampicin microspheres obtained by freezing induced LLPS during lyophilization.

International journal of pharmaceutics

Liu C, Kong C, Wu G, Zhu J, Javid B, Qian F

Transmitted Extended-Spectrum Extensively Drug-Resistant Tuberculosis in Beijing, China, with Discordant Whole-Genome Sequencing Analysis Results.

Journal of clinical microbiology

Li H, Kayani Mu, Gu Y, Wang X, Zhu T, Duan H, Ma Y, Huang H, Javid B

Tuberculosis: hey there, lonely guy!

Molecular cell

Zhu JH, Javid B

Drug-resistance mechanisms and tuberculosis drugs.

Lancet (London, England)

Köser CU, Javid B, Liddell K, Ellington MJ, Feuerriegel S, Niemann S, Brown NM, Burman WJ, Abubakar I, Ismail NA, Moore D, Peacock SJ, Török ME

Protein mistranslation: friend or foe?

Trends in biochemical sciences

Ribas de Pouplana L, Santos MA, Zhu JH, Farabaugh PJ, Javid B

Prevalence and drug resistance of nontuberculous mycobacteria, northern China, 2008-2011.

Emerging infectious diseases

Wang X, Li H, Jiang G, Zhao L, Ma Y, Javid B, Huang H

Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance.

Proceedings of the National Academy of Sciences of the United States of America

Javid B, Sorrentino F, Toosky M, Zheng W, Pinkham JT, Jain N, Pan M, Deighan P, Rubin EJ

Functional role of methylation of G518 of the 16S rRNA 530 loop by GidB in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy

Wong SY, Javid B, Addepalli B, Piszczek G, Strader MB, Limbach PA, Barry CE

MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212.

Antimicrobial agents and chemotherapy

La Rosa V, Poce G, Canseco JO, Buroni S, Pasca MR, Biava M, Raju RM, Porretta GC, Alfonso S, Battilocchio C, Javid B, Sorrentino F, Ioerger TR, Sacchettini JC, Manetti F, Botta M, De Logu A, Rubin EJ, De Rossi E

Nanotubes: shaking hands, talking, or sharing?

Frontiers in microbiology

Javid B, Derbyshire KM

Human H+ATPase a4 subunit mutations causing renal tubular acidosis reveal a role for interaction with phosphofructokinase-1.

American journal of physiology. Renal physiology

Su Y, Blake-Palmer KG, Sorrell S, Javid B, Bowers K, Zhou A, Chang SH, Qamar S, Karet FE

A 58-year-old woman with abdominal symptoms and elevated C-reactive protein.

PLoS medicine

Daly ML, Cartwright DJ, Lehner PJ, Javid B

A case of Mycoplasma hominis septic arthritis postpartum.

The Journal of infection

Phuah CL, Javid B, Aliyu SH, Lever AM

Structure and function: heat shock proteins and adaptive immunity.

Journal of immunology (Baltimore, Md. : 1950)

Javid B, MacAry PA, Lehner PJ

Schistosomal colonic polyposis in an HIV-positive man.

AIDS (London, England)

Javid B, Aliyu SH, Save VE, Carmichael AJ, Lever AM

Peptides complexed with the protein HSP70 generate efficient human cytolytic T-lymphocyte responses.

Biochemical Society transactions

Javid B, MacAry PA, Oehlmann W, Singh M, Lehner PJ

Molecular studies of anti-HLA-A2 using light-chain shuffling: a structural model for HLA antibody binding.

Tissue antigens

Watkins NA, Dafforn TR, Kuijpers M, Brown C, Javid B, Lehner PJ, Navarrete C, Ouwehand WH

HSP70 peptide binding mutants separate antigen delivery from dendritic cell stimulation.

Immunity

MacAry PA, Javid B, Floto RA, Smith KG, Oehlmann W, Singh M, Lehner PJ

High rates of tuberculosis in end-stage renal failure: the impact of international migration.

Emerging infectious diseases

Moore DA, Lightstone L, Javid B, Friedland JS