Christina Yoon, MD, MPH

Associate Professor In Res
Medicine
[email protected]
+1 628 206-3514

My research is focused on identifying accurate and affordable TB diagnostic tools to improve the efficiency of TB diagnosis and delivery of TB preventive therapy for high-risk populations in resource-limited settings. I have experience in leading international studies of diagnostic accuracy and longitudinal cohort studies. 

Publications: 

Point-of-care C-reactive protein and Xpert MTB/RIF Ultra for tuberculosis screening and diagnosis in unselected antiretroviral therapy initiators: a prospective, cross-sectional, diagnostic accuracy study.

The Lancet. Global health

Reeve BWP, Ndlangalavu G, Mishra H, Palmer Z, Tshivhula H, Rockman L, Naidoo S, Mbu DL, Naidoo CC, Derendinger B, Walzl G, Malherbe ST, van Helden PD, Semitala FC, Yoon C, Gupta RK, Noursadeghi M, Warren RM, Theron G

Clinical utility of WHO-recommended screening tools and development and validation of novel clinical prediction models for pulmonary tuberculosis screening among outpatients living with HIV: an individual participant data meta-analysis.

European respiratory review : an official journal of the European Respiratory Society

Dhana A, Gupta RK, Hamada Y, Kengne AP, Kerkhoff AD, Yoon C, Cattamanchi A, Reeve BWP, Theron G, Ndlangalavu G, Wood R, Drain PK, Calderwood CJ, Noursadeghi M, Boyles T, Meintjes G, Maartens G, Barr DA

Point-of-care C-reactive protein and Xpert MTB/RIF Ultra for tuberculosis screening and diagnosis in unselected antiretroviral therapy initiators: a prospective diagnostic accuracy study.

medRxiv : the preprint server for health sciences

Reeve BW, Ndlangalavu G, Mishra H, Palmer Z, Tshivhula H, Rockman L, Naidoo S, Mbu DL, Naidoo CC, Derendinger B, Walzl G, Malherbe ST, van Helden PD, Semitala FC, Yoon C, Gupta RK, Noursadeghi M, Warren RM, Theron G

Diagnostic yield of urine lipoarabinomannan and sputum tuberculosis tests in people living with HIV: a systematic review and meta-analysis of individual participant data.

The Lancet. Global health

Broger T, Koeppel L, Huerga H, Miller P, Gupta-Wright A, Blanc FX, Esmail A, Reeve BWP, Floridia M, Kerkhoff AD, Ciccacci F, Kasaro MP, Thit SS, Bastard M, Ferlazzo G, Yoon C, Van Hoving DJ, Sossen B, García JI, Cummings MJ, Wake RM, Hanson J, Cattamanchi A, Meintjes G, Maartens G, Wood R, Theron G, Dheda K, Olaru ID, Denkinger CM, TBYield Study Consortium

Viral suppression among adults with HIV receiving routine dolutegravir-based antiretroviral therapy and 3HP.

AIDS (London, England)

Chaisson LH, Semitala FC, Nangobi F, Steinmetz S, Marquez C, Armstrong DT, Opira B, Kamya MR, Phillips PPJ, Dowdy DW, Yoon C

The Role of C-Reactive Protein as a Triage Tool for Pulmonary Tuberculosis in Children.

Journal of the Pediatric Infectious Diseases Society

Jaganath D, Reza TF, Wambi P, Nakafeero J, Kiconco E, Nanyonga G, Oumo EA, Nsereko MC, Sekadde MP, Nabukenya-Mudiope MG, Kato-Maeda M, Andama A, Yoon C, Mohanty S, Wobudeya E, Cattamanchi A

Transaminitis prevalence among HIV-infected adults eligible for tuberculosis preventive therapy.

AIDS (London, England)

Chaisson LH, Semitala FC, Mwebe S, Katende J, Asege L, Nakaye M, Andama AO, Atuhumuza E, Kamya M, Cattamanchi A, Yoon C

Tuberculosis screening among ambulatory people living with HIV: a systematic review and individual participant data meta-analysis.

The Lancet. Infectious diseases

Dhana A, Hamada Y, Kengne AP, Kerkhoff AD, Rangaka MX, Kredo T, Baddeley A, Miller C, Singh S, Hanifa Y, Grant AD, Fielding K, Affolabi D, Merle CS, Wachinou AP, Yoon C, Cattamanchi A, Hoffmann CJ, Martinson N, Mbu ET, Sander MS, Balcha TT, Skogmar S, Reeve BWP, Theron G, Ndlangalavu G, Modi S, Cavanaugh J, Swindells S, Chaisson RE, Ahmad Khan F, Howard AA, Wood R, Thit SS, Kyi MM, Hanson J, Drain PK, Shapiro AE, Kufa T, Churchyard G, Nguyen DT, Graviss EA, Bjerrum S, Johansen IS, Gersh JK, Horne DJ, LaCourse SM, Al-Darraji HAA, Kamarulzaman A, Kempker RR, Tukvadze N, Barr DA, Meintjes G, Maartens G

C-Reactive Protein for Active Tuberculosis Among Inpatients without HIV in Uganda: A Diagnostic Accuracy Study.

Journal of clinical microbiology

Meyer AJ, Ochom E, Turimumahoro P, Byanyima P, Sanyu I, Lalitha R, Kaswabuli S, Andama A, Walter ND, Katamba A, Cattamanchi A, Worodria W, Huang L, Yoon C, Davis JL

Impact of hematocrit on point-of-care C-reactive protein-based tuberculosis screening among people living with HIV initiating antiretroviral therapy in Uganda.

Diagnostic microbiology and infectious disease

Mwebe SZ, Yoon C, Asege L, Nakaye M, Katende J, Andama A, Cattamanchi A, Semitala FC

Evaluation of multi-antigen serological screening for active tuberculosis among people living with HIV.

PloS one

Jaganath D, Rajan J, Yoon C, Ravindran R, Andama A, Asege L, Mwebe SZ, Katende J, Nakaye M, Semitala FC, Khan IH, Cattamanchi A

Management and Outcomes of Critically-Ill Patients with COVID-19 Pneumonia at a Safety-net Hospital in San Francisco, a Region with Early Public Health Interventions: A Case Series.

medRxiv : the preprint server for health sciences

Vanderburg S, Alipanah N, Crowder R, Yoon C, Wang R, Thakur N, Slown K, Shete PB, Rofael M, Metcalfe JZ, Merrifield C, Marquez C, Malcolm K, Lipnick M, Jain V, Gomez A, Burns G, Brown LB, Berger C, Auyeung V, Cattamanchi A, Hendrickson CM

Brief Report: Yield and Efficiency of Intensified Tuberculosis Case-Finding Algorithms in 2 High-Risk HIV Subgroups in Uganda.

Journal of acquired immune deficiency syndromes (1999)

Semitala FC, Cattamanchi A, Andama A, Atuhumuza E, Katende J, Mwebe S, Asege L, Nakaye M, Kamya MR, Yoon C

Guidance for Studies Evaluating the Accuracy of Tuberculosis Triage Tests.

The Journal of infectious diseases

Nathavitharana RR, Yoon C, Macpherson P, Dowdy DW, Cattamanchi A, Somoskovi A, Broger T, Ottenhoff THM, Arinaminpathy N, Lonnroth K, Reither K, Cobelens F, Gilpin C, Denkinger CM, Schumacher SG

A Novel, 5-Transcript, Whole-blood Gene-expression Signature for Tuberculosis Screening Among People Living With Human Immunodeficiency Virus.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Rajan JV, Semitala FC, Mehta T, Seielstad M, Montalvo L, Andama A, Asege L, Nakaye M, Katende J, Mwebe S, Kamya MR, Yoon C, Cattamanchi A

Point-of-care C-reactive protein and risk of early mortality among adults initiating antiretroviral therapy.

AIDS (London, England)

Chaisson LH, Semitala FC, Asege L, Mwebe S, Katende J, Nakaye M, Andama AO, Marquez C, Atuhumuza E, Kamya M, Cattamanchi A, Yoon C

Reply to Parker: Implications of Tuberculosis Sputum Culture Test Sensitivity on Accuracy of Other Diagnostic Modalities.

American journal of respiratory and critical care medicine

Yoon C, Semitala FC, Cattamanchi A

Screening for tuberculosis: time to move beyond symptoms.

The Lancet. Respiratory medicine

Yoon C, Dowdy DW, Esmail H, MacPherson P, Schumacher SG

Yield and Efficiency of Novel Intensified Tuberculosis Case-Finding Algorithms for People Living with HIV.

American journal of respiratory and critical care medicine

Yoon C, Semitala FC, Asege L, Katende J, Mwebe S, Andama AO, Atuhumuza E, Nakaye M, Armstrong DT, Dowdy DW, McCulloch CE, Kamya M, Cattamanchi A

Diagnostic performance of blood inflammatory markers for tuberculosis screening in people living with HIV.

PloS one

Farr K, Ravindran R, Strnad L, Chang E, Chaisson LH, Yoon C, Worodria W, Andama A, Ayakaka I, Bbosa Nalwanga P, Byanyima P, Kalema N, Kaswabuli S, Katagira W, Aman KD, Musisi E, Tumwine NW, Sanyu I, Ssebunya R, Davis JL, Huang L, Khan IH, Cattamanchi A

Diagnostic accuracy of C-reactive protein for active pulmonary tuberculosis: a meta-analysis.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

Yoon C, Chaisson LH, Patel SM, Allen IE, Drain PK, Wilson D, Cattamanchi A

Point-of-care C-reactive protein-based tuberculosis screening for people living with HIV: a diagnostic accuracy study.

The Lancet. Infectious diseases

Yoon C, Semitala FC, Atuhumuza E, Katende J, Mwebe S, Asege L, Armstrong DT, Andama AO, Dowdy DW, Davis JL, Huang L, Kamya M, Cattamanchi A

Blood Transcriptional Biomarkers for Active Tuberculosis among Patients in the United States: a Case-Control Study with Systematic Cross-Classifier Evaluation.

Journal of clinical microbiology

Walter ND, Miller MA, Vasquez J, Weiner M, Chapman A, Engle M, Higgins M, Quinones AM, Rosselli V, Canono E, Yoon C, Cattamanchi A, Davis JL, Phang T, Stearman RS, Datta G, Garcia BJ, Daley CL, Strong M, Kechris K, Fingerlin TE, Reves R, Geraci MW

Serum biomarkers of treatment response within a randomized clinical trial for pulmonary tuberculosis.

Tuberculosis (Edinburgh, Scotland)

Jayakumar A, Vittinghoff E, Segal MR, MacKenzie WR, Johnson JL, Gitta P, Saukkonen J, Anderson J, Weiner M, Engle M, Yoon C, Kato-Maeda M, Nahid P

Point-of-care C-reactive protein testing to facilitate implementation of isoniazid preventive therapy for people living with HIV.

Journal of acquired immune deficiency syndromes (1999)

Yoon C, Davis JL, Huang L, Muzoora C, Byakwaga H, Scibetta C, Bangsberg DR, Nahid P, Semitala FC, Hunt PW, Martin JN, Cattamanchi A

Absence of peripheral blood chimerism in graft-vs-host disease following orthotopic liver transplantation: case report and review of the literature.

International journal of dermatology

Schulman JM, Yoon C, Schwarz J, Vagefi PA, Mully TW, Shinkai K

C-reactive protein and tuberculosis screening: a new trick for an old dog?

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

Yoon C, Davis JL, Cattamanchi A

Dihydropteroate synthase mutations in Pneumocystis pneumonia: impact of applying different definitions of prophylaxis, mortality endpoints and mutant in a single cohort.

Medical mycology

Yoon C, Subramanian A, Chi A, Crothers K, Meshnick SR, Taylor SM, Beard CB, Jarlsberg LG, Lawrence GG, Avery M, Swartzman A, Fong S, Roth B, Huang L

Impact of Xpert MTB/RIF testing on tuberculosis management and outcomes in hospitalized patients in Uganda.

PloS one

Yoon C, Cattamanchi A, Davis JL, Worodria W, den Boon S, Kalema N, Katagira W, Kaswabuli S, Miller C, Andama A, Albert H, Nabeta P, Gray C, Ayakaka I, Huang L