Felicia Chow, MD

Assoc Prof of Clin Neurology
Neurology

My research focus is at the intersection of HIV and the brain, with a specific interest in HIV-associated cerebrovascular disease and TB meningitis. The goal of my work is to develop targetedinterventions to preserve neurological health in persons living with HIV in diverse settings. I am currently leading a phase 2 clinical trial investigating the pharmacokinetics of linezolid administered with high dose rifampin in the treatment of TB meningitis in persons living with HIV in Uganda. I am also involved in the development of an AIDS Clinical Trials Group multisite trial of high dose rifampin, high dose isoniazid, and linezolid to improve mortality and neurologic outcomes in TB meningitis, on which I serve in the role of co-chair. As a board-certified neurologist and neuro-infectious diseases subspecialist with formal fellowship training in infectious diseases, I maintain an active clinical practice in neurology and neuro-infectious diseases, attending on the neurology inpatient ward and consult service at Zuckerberg San Francisco General Hospital. I also direct the UCSF Neuro-Infectious Diseases Clinic, a clinic embedded within the Infectious Diseases Clinic on the UCSF Parnassus campus, where we care for patients with a wide variety of neurological infections. In this capacity, I provide consultation for challenging management issues that arise in cases of central nervous system TB. 

Publications: 

Sex Differences in the Risk of Stroke Associated With Traditional and Non-Traditional Factors in a US Cohort of People With HIV Infection.

Neurology

Chow FC, Nance RM, Becker K, Ho EL, Huffer A, Kalani R, Marra CM, Zunt JR, Bamford L, Burkholder GA, Cachay E, Eron JJ, Keruly J, Kitahata MM, Napravnik S, Saag MS, Willig AL, Moore RD, Tirschwell DL, Delaney JA, Crane HM, as the CFAR Network of Integrated Clinical Systems (CNICS) Cohort Study

Progressive multifocal leukoencephalopathy and spectrum of predisposing conditions: a 20-year retrospective cohort study in a tertiary center in São Paulo, Brazil.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Mari JF, de Miranda ÉJFP, Mendes-Correa MC, Chow FC, Vidal JE

A teenage girl with altered mental status and paraparesis.

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases

Miyakawa R, Louie J, Keh C, Chen L, Javid B, Ernst JD, Goswami N, Chow FC

Outcome and Sequelae of Autoimmune Encephalitis.

Journal of clinical neurology (Seoul, Korea)

Kvam KA, Stahl JP, Chow FC, Soldatos A, Tattevin P, Sejvar J, Mailles A

Outcome and Sequelae of Infectious Encephalitis.

Journal of clinical neurology (Seoul, Korea)

Kvam KA, Stahl JP, Chow FC, Soldatos A, Tattevin P, Sejvar J, Mailles A

Advancing Diagnosis and Treatment in People Living with HIV and Tuberculosis Meningitis.

Current HIV/AIDS reports

Kimuda S, Kasozi D, Namombwe S, Gakuru J, Mugabi T, Kagimu E, Rutakingirwa MK, Leon KE, Chow F, Wasserman S, Boulware DR, Cresswell FV, Bahr NC

HIV Infection and 90-Day Stroke Outcomes in Uganda: A Prospective Observational Cohort Study.

Neurology. Clinical practice

Mbonde AA, Chang J, Musubire AK, Okello S, Kayanja A, Moses A, Butterfield RJ, Chow FC, Saylor DR, O'Carroll CB, Siedner M

Psychological stress is associated with arterial inflammation in people living with treated HIV infection.

Brain, behavior, and immunity

Chow FC, Mundada NS, Abohashem S, La Joie R, Iaccarino L, Arechiga VM, Swaminathan S, Rabinovici GD, Epel ES, Tawakol A, Hsue PY

Consensus Competencies for Post-Graduate Fellowship Training in Global Neurology.

Neurology

Schiess N, Kulo V, Anand P, Bearden DR, Berkowitz AL, Birbeck GL, Cervantes-Arslanian A, Chan P, Chishimba LC, Chow FC, Elicer I, Fleury A, Kinikar A, Kvalsund M, Mateen FJ, Mbonde AA, Meyer AL, O'Carroll CB, Ogunniyi A, Patel AA, Rubenstein M, Siddiqi OK, Spudich S, Tackett SA, Thakur KT, Vora N, Zunt J, Saylor DR

Cognitive Health in Persons With Human Immunodeficiency Virus: The Impact of Early Treatment, Comorbidities, and Aging.

The Journal of infectious diseases

Aung HL, Alagaratnam J, Chan P, Chow FC, Joska J, Falutz J, Letendre SL, Lin W, Muñoz-Moreno JA, Cinque P, Taylor J, Brew B, Winston A

Sex differences in the association between cerebrovascular function and cognitive health in people living with HIV in urban China.

Journal of acquired immune deficiency syndromes (1999)

Chow FC, Zhao F, He Y, Song X, Zhang J, Ao D, Wu Y, Hou B, Sorond FA, Ances BM, Letendre S, Heaton RK, Shi C, Feng F, Zhu Y, Wang H, Li T

Dual ankyrinG and subpial autoantibodies in a man with well-controlled HIV infection with steroid-responsive meningoencephalitis: A case report.

Frontiers in neurology

Bartley CM, Ngo TT, Cadwell CR, Harroud A, Schubert RD, Alvarenga BD, Hawes IA, Zorn KC, Hunyh T, Teliska LH, Kung AF, Shah S, Gelfand JM, Chow FC, Rasband MN, Dubey D, Pittock SJ, DeRisi JL, Wilson MR, Pleasure SJ

Glucocorticoid receptor function and cognitive performance in women with HIV.

Psychosomatic medicine

Rubin LH, Bekhbat M, Turkson S, Mehta CC, Maki PM, Anastos K, Gustafson D, Spence AB, Milam J, Chow FC, Weber K, Springer G, Gange SJ, Neigh GN

Plasma Markers of Neurologic Injury and Inflammation in People With Self-Reported Neurologic Postacute Sequelae of SARS-CoV-2 Infection.

Neurology(R) neuroimmunology & neuroinflammation

Peluso MJ, Sans HM, Forman CA, Nylander AN, Ho HE, Lu S, Goldberg SA, Hoh R, Tai V, Munter SE, Chenna A, Yee BC, Winslow JW, Petropoulos CJ, Martin JN, Kelly JD, Durstenfeld MS, Hsue PY, Hunt PW, Greene M, Chow FC, Hellmuth J, Henrich TJ, Glidden DV, Deeks SG

Prevalence and Characteristics of HIV-Associated Stroke in a Tertiary Hospital Setting in South Africa.

Neurology

Corbett C, Brey N, Pitcher RD, O'Hagan S, Esterhuizen TM, Chow FC, Decloedt EH

A comprehensive analysis of stroke risk factors by HIV serostatus in Uganda: Implications for stroke prevention in sub-Saharan Africa (P1-1.Virtual).

Neurology

Amir Mbonde, Jonathan Chang, Kisekka Musubire, Samson Okello, Adrian Kayanja, Acan Moses, Jacob Nkwanga, Andrew Katende, Felicia Chow, Deanna Saylor, Cumara O'Carroll, Mark Siedner

An analysis of stroke risk factors by HIV serostatus in Uganda: Implications for stroke prevention in sub-Saharan Africa.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Mbonde AA, Chang J, Musubire A, Okello S, Kayanja A, Acan M, Nkwanga J, Katende A, Chow FC, Saylor D, O'Carroll C, Siedner MJ

Infectious Meningitis and Encephalitis.

Neurologic clinics

Bystritsky RJ, Chow FC

Intracranial vascular imaging detects arterial wall abnormalities in persons with treated HIV infection.

AIDS (London, England)

Chow FC, Callen A, Arechiga V, Saloner D, Narvid J, Hsue PY

Central Nervous System Effects of COVID-19 in People with HIV Infection.

Current HIV/AIDS reports

Peluso MJ, Hellmuth J, Chow FC

Elevated Plasma von Willebrand Factor Levels Are Associated With Subsequent Ischemic Stroke in Persons With Treated HIV Infection.

Open forum infectious diseases

Graham SM, Nance RM, Chen J, Le J, Chung DW, Wurfel MM, Tirschwell DL, Zunt JR, Marra CM, Ho EL, Huffer A, Chow FC, Martin JN, Ryan AS, Crane HM, López JA, Liles WC

Neurosyphilis.

Continuum (Minneapolis, Minn.)

Chow F

Types of Stroke Among People Living With HIV in the United States.

Journal of acquired immune deficiency syndromes (1999)

Crane HM, Nance RM, Avoundjian T, Harding BN, Whitney BM, Chow FC, Becker KJ, Marra CM, Zunt JR, Ho EL, Kalani R, Huffer A, Burkholder GA, Willig AL, Moore RD, Mathews WC, Eron JJ, Napravnik S, Lober WB, Barnes GS, McReynolds J, Feinstein MJ, Heckbert SR, Saag MS, Kitahata MM, Delaney JAC, Tirschwell DL

Cocaine Use and White Matter Hyperintensities in Homeless and Unstably Housed Women.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Factors associated with worse cerebrovascular function in aging women with and at risk for HIV.

AIDS (London, England)

Chow FC, Ma Y, Manion M, Rupert A, Lambert-Messerlian G, Bushnell CD, Cedars MI, Sereti I, Sorond FA, Hsue PY, Tien PC

Persistent COVID-19-associated neurocognitive symptoms in non-hospitalized patients.

Journal of neurovirology

Hellmuth J, Barnett TA, Asken BM, Kelly JD, Torres L, Stephens ML, Greenhouse B, Martin JN, Chow FC, Deeks SG, Greene M, Miller BL, Annan W, Henrich TJ, Peluso MJ

Baseline 10-year cardiovascular risk scores predict cognitive function in older persons, and particularly women, living with HIV infection.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Chow FC, Lyass A, Mahoney TF, Massaro JM, Triant VA, Wu K, Berzins B, Robertson K, Ellis RJ, Tassiopoulos K, Taiwo B, D'Agostino RB

Xpert MTB/RIF Ultra for the Diagnosis of Tuberculous Meningitis: A Small Step Forward.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Donovan J, Cresswell FV, Thuong NTT, Boulware DR, Thwaites GE, Bahr NC

The regional pattern of abnormal cerebrovascular reactivity in HIV-infected, virally suppressed women.

Journal of neurovirology

Callen AL, Dupont SM, Pyne J, Talbott J, Tien P, Calabrese E, Saloner D, Chow FC, Narvid J

Standardized approaches for clinical sampling and endpoint ascertainment in tuberculous meningitis studies.

Wellcome open research

Rohlwink UK, Chow FC, Wasserman S, Dian S, Lai RP, Chaidir L, Hamers RL, Wilkinson RJ, Boulware DR, Cresswell FV, van Laarhoven A

A rare case of HIV CNS escape in a patient previously considered a viral controller.

International journal of STD & AIDS

Magid-Bernstein J, Guo CY, Chow FC, Thakur KT

Prevention of stroke in people living with HIV.

Progress in cardiovascular diseases

Nguyen I, Kim AS, Chow FC

Tuberculous meningitis: new tools and new approaches required.

Wellcome open research

Seddon JA, Thwaites GE

Neurocognitive and functional impairment in adult and paediatric tuberculous meningitis.

Wellcome open research

Davis AG, Nightingale S, Springer PE, Solomons R, Arenivas A, Wilkinson RJ, Anderson ST, Chow FC

Management of intracranial tuberculous mass lesions: how long should we treat for?

Wellcome open research

Marais S, Van Toorn R, Chow FC, Manesh A, Siddiqi OK, Figaji A, Schoeman JF, Meintjes G

Association Between Bilirubin, Atazanavir, and Cardiovascular Disease Events Among People Living With HIV Across the United States.

Journal of acquired immune deficiency syndromes (1999)

Crane HM, Nance RM, Heckbert SR, Ritchings C, Rosenblatt L, Budoff M, Wood BR, Tirschwell DL, Kim HN, Mathews WC, Geng E, Moore RD, Hunt PW, Eron JJ, Burkholder GA, Drozd DR, Chow FC, Becker KJ, Zunt JR, Ho EL, Kalani R, Huffer A, Whitney BM, Saag MS, Kitahata MM, Delaney JAC

Building a neuroinfectious disease consensus curriculum.

Neurology

Venkatesan A, Chow FC, Aksamit A, Bartt R, Bleck TP, Jay C, Pastula DM, Roos KL, Rumbaugh J, Saylor D, Cho TA

Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis.

The New England journal of medicine

Wilson MR, Sample HA, Zorn KC, Arevalo S, Yu G, Neuhaus J, Federman S, Stryke D, Briggs B, Langelier C, Berger A, Douglas V, Josephson SA, Chow FC, Fulton BD, DeRisi JL, Gelfand JM, Naccache SN, Bender J, Dien Bard J, Murkey J, Carlson M, Vespa PM, Vijayan T, Allyn PR, Campeau S, Humphries RM, Klausner JD, Ganzon CD, Memar F, Ocampo NA, Zimmermann LL, Cohen SH, Polage CR, DeBiasi RL, Haller B, Dallas R, Maron G, Hayden R, Messacar K, Dominguez SR, Miller S, Chiu CY

Global Teleneurology Service: First Insights (P2.6-045).

Neurology

Riley Bove, Jalayne Arias, Andrew Barnecut, Linda Branagan, Felicia Chow, Jeffrey Gelfand, S. Andrew Josephson, Maya Katz, Catherine Lomen-Hoerth, Erica Schleimer, Nilika Singhal, Michael Wilson, Theodore Niyongabo, Aliza Norwood, Claudia Kaneza, Elizabeth Kohnen, Cathryn Christensen, Jon Van Leeuwen

Physical Activity Is Associated With Lower Odds of Cognitive Impairment in Women but Not Men Living With Human Immunodeficiency Virus Infection.

The Journal of infectious diseases

Chow FC, Makanjuola A, Wu K, Berzins B, Kim KA, Ogunniyi A, Ellis RJ, Robertson K, Tassiopoulos K, Taiwo BO

Stroke in HIV.

The Canadian journal of cardiology

Bogorodskaya M, Chow FC, Triant VA

Validation of the Intracerebral Hemorrhage Score in Uganda.

Stroke

Abdallah A, Chang JL, O'Carroll CB, Okello S, Olum S, Acan M, Aden AA, Chow FC, Siedner MJ

Cerebral Vasoreactivity Evaluated by the Breath-Holding Challenge Correlates With Performance on a Cognitive Screening Test in Persons Living With Treated HIV Infection in China.

Journal of acquired immune deficiency syndromes (1999)

Chow FC, Wang H, Li Y, Mehta N, Hu Y, Han Y, Xie J, Lu W, Xu W, Li T

Brain and Spinal Epidural Abscess.

Continuum (Minneapolis, Minn.)

Chow F

Detection of (1,3)-ß-d-Glucan in Cerebrospinal Fluid in Histoplasma Meningitis.

Journal of clinical microbiology

Myint T, Chow FC, Bloch KC, Raymond-Guillen L, Davis TE, Wright PW, Woc-Colburn L, Khairy RN, Street AC, Yamamoto T, Albers A, Wheat LJ, Hage CA

Brain MRI Features of CSF Human Immunodeficiency Virus Escape.

Journal of neuroimaging : official journal of the American Society of Neuroimaging

Narvid J, Callen A, Talbott J, Uzelac A, Dupont SM, Chow F, Price RW, Rehani B

Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing.

JAMA neurology

Wilson MR, O'Donovan BD, Gelfand JM, Sample HA, Chow FC, Betjemann JP, Shah MP, Richie MB, Gorman MP, Hajj-Ali RA, Calabrese LH, Zorn KC, Chow ED, Greenlee JE, Blum JH, Green G, Khan LM, Banerji D, Langelier C, Bryson-Cahn C, Harrington W, Lingappa JR, Shanbhag NM, Green AJ, Brew BJ, Soldatos A, Strnad L, Doernberg SB, Jay CA, Douglas V, Josephson SA, DeRisi JL

Stroke incidence is highest in women and non-Hispanic blacks living with HIV in the AIDS Clinical Trials Group Longitudinal Linked Randomized Trials cohort.

AIDS

Felicia C. Chow, Michael R. Wilson, Kunling Wu, Ronald J. Ellis, Ronald J. Bosch, Benjamin P. Linas

Stroke in Human Immunodeficiency Virus-infected Individuals in Sub-Saharan Africa (SSA): A Systematic Review.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Abdallah A, Chang JL, O'Carroll CB, Musubire A, Chow FC, Wilson AL, Siedner MJ

Improvement in Diagnosis of Histoplasma Meningitis by Combined Testing for Histoplasma Antigen and Immunoglobulin G and Immunoglobulin M Anti-Histoplasma Antibody in Cerebrospinal Fluid.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Bloch KC, Myint T, Raymond-Guillen L, Hage CA, Davis TE, Wright PW, Chow FC, Woc-Colburn L, Khairy RN, Street AC, Yamamoto T, Albers A, Wheat LJ

Elevated ischemic stroke risk among women living with HIV infection.

AIDS (London, England)

Chow FC, Regan S, Zanni MV, Looby SE, Bushnell CD, Meigs JB, Grinspoon SK, Feske SK, Triant VA

Pleocytosis is not fully responsible for low CSF glucose in meningitis.

Neurology(R) neuroimmunology & neuroinflammation

Baud MO, Vitt JR, Robbins NM, Wabl R, Wilson MR, Chow FC, Gelfand JM, Josephson SA, Miller S

Sex Matters in Neuroinfectious Diseases.

Seminars in neurology

Chow FC

Central Nervous System Infections Associated with Immunosuppressive Therapy for Rheumatic Disease.

Rheumatic diseases clinics of North America

Bradshaw MJ, Cho TA, Chow FC

Incidence of Stroke in the US Centers for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) Cohort (S51.008).

Neurology

David Tirschwell, Felicia Chow, Kyra Becker, Christina Marra, Joseph Zunt, Emily Ho, Rizwan Kalani, Andrew Huffer, Robin Nance, Jessica Williams-Nguyen, Greer Burkholder, Richard Moore, William Mathews, Joseph Eron, Daniel Drozd, Mari Kitahata, Michael Saag, Heidi Crane

Greater Risk of Stroke of Undetermined Etiology in a Contemporary HIV-Infected Cohort Compared with Uninfected Individuals.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Chow FC, Price RW, Hsue PY, Kim AS

Relationship Between HIV Infection, Antiretroviral Therapy, Inflammatory Markers, and Cerebrovascular Endothelial Function Among Adults in Urban China.

Journal of acquired immune deficiency syndromes (1999)

Chow FC, Li Y, Hu Y, Chan J, Wang H, Xu W, Price RW, Sorond FA, Li T

Neurologic Complications in Treated HIV-1 Infection.

Current neurology and neuroscience reports

Bhatia NS, Chow FC

Identification of cellular targets of a series of boron heterocycles using TIPA II-A sensitive target identification platform.

Bioorganic & medicinal chemistry

Ward MS, Silva I, Martinez W, Jefferson J, Rahman S, Garcia JM, Kanichar D, Roppiyakuda L, Kosmowska E, Faust MA, Tran KP, Chow F, Buglo E, Zhou F, Groziak MP, Xu HH

Cerebral vasoreactivity is impaired in treated, virally suppressed HIV-infected individuals.

AIDS (London, England)

Chow FC, Boscardin WJ, Mills C, Ko N, Carroll C, Price RW, Deeks S, Sorond FA, Hsue PY

Endothelial function and CNS measures in primary HIV infection pre-and post early ART (P2.314).

Neurology

Sebastian Urday, Zaina Zayyad, Julia Peterson, Felicia Chow, Kevin Robertson, Richard Price, Priscilla Hsue, Serena Spudich

Multicenter cohort study of diabetes mellitus and impaired fasting glucose in HIV-infected patients in China.

Journal of acquired immune deficiency syndromes (1999)

Zhang C, Chow FC, Han Y, Xie J, Qiu Z, Guo F, Li Y, Wang H, Li T

Use of clinical and neuroimaging characteristics to distinguish temporal lobe herpes simplex encephalitis from its mimics.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Chow FC, Glaser CA, Sheriff H, Xia D, Messenger S, Whitley R, Venkatesan A

Effect of CD4+ cell count and viral suppression on risk of ischemic stroke in HIV infection.

AIDS (London, England)

Chow FC, Bacchetti P, Kim AS, Price RW, Hsue PY

Elevated rates of intracerebral hemorrhage in individuals from a US clinical care HIV cohort.

Neurology

Chow FC, He W, Bacchetti P, Regan S, Feske SK, Meigs JB, Grinspoon SK, Triant VA

Emerging and reemerging neurologic infections.

The Neurohospitalist

Chow FC, Glaser CA

HIV infection and incidence of ischemic stroke.

AIDS (London, England)

Marcus JL, Leyden WA, Chao CR, Chow FC, Horberg MA, Hurley LB, Klein DB, Quesenberry CP, Towner WJ, Silverberg MJ

HIV infection, vascular disease, and stroke.

Seminars in neurology

Chow FC

Incidence Rates of Intracerebral Hemorrhage Are Increased in Young and Female HIV-Infected Individuals (S38.004).

Neurology

Felicia Chow, Susan Regan, Wei He, Steven Feske, James Meigs, Steven Grinspoon, Virginia Triant

Comparison of ischemic stroke incidence in HIV-infected and non-HIV-infected patients in a US health care system.

Journal of acquired immune deficiency syndromes (1999)

Chow FC, Regan S, Feske S, Meigs JB, Grinspoon SK, Triant VA

Cerebrovascular disease in central nervous system infections.

Seminars in neurology

Chow FC, Marra CM, Cho TA

National outbreak of Acanthamoeba keratitis associated with use of a contact lens solution, United States.

Emerging infectious diseases

Verani JR, Lorick SA, Yoder JS, Beach MJ, Braden CR, Roberts JM, Conover CS, Chen S, McConnell KA, Chang DC, Park BJ, Jones DB, Visvesvara GS, Roy SL

Burden of neuroinfectious diseases on the neurology service in a tertiary care center.

Neurology

Tan K, Patel S, Gandhi N, Chow F, Rumbaugh J, Nath A

La cuerda dulce--a tolerability and acceptability study of a novel approach to specimen collection for diagnosis of paediatric pulmonary tuberculosis.

BMC infectious diseases

Chow F, Espiritu N, Gilman RH, Gutierrez R, Lopez S, Escombe AR, Evans CA, Moore DA