Jason Sello, PhD

Small molecules restore azole activity against drug-tolerant and drug-resistant Candida isolates.

mBio

Alabi PE, Gautier C, Murphy TP, Gu X, Lepas M, Aimanianda V, Sello JK, Ene IV

Hydroxyl-Rich Hydrophilic Endocytosis-Promoting Peptide with No Positive Charge.

Journal of the American Chemical Society

Wang S, Li Z, Aispuro D, Guevara N, Van Valkenburgh J, Chen B, Zhou X, McCarroll MN, Ji F, Cong X, Sarkar P, Chaudhuri R, Guo Z, Perkins NP, Shao S, Sello JK, Chen K, Xue M

Acyldepsipeptide Antibiotics and a Bioactive Fragment Thereof Differentially Perturb Mycobacterium tuberculosis ClpXP1P2 Activity in vitro.

ACS chemical biology

Schmitz KR, Handy EL, Compton CL, Gupta S, Bishai WR, Sauer RT, Sello JK

Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections.

Frontiers in cellular and infection microbiology

Craig E, Calarco A, Conte R, Ambrogi V, d'Ayala GG, Alabi P, Sello JK, Cerruti P, Kima PE

Discovery of Retro-1 Analogs Exhibiting Enhanced Anti-vaccinia Virus Activity.

Frontiers in microbiology

Priyamvada L, Alabi P, Leon A, Kumar A, Sambhara S, Olson VA, Sello JK, Satheshkumar PS

Principles of Information Storage in Small-Molecule Mixtures.

IEEE transactions on nanobioscience

Rosenstein JK, Rose C, Reda S, Weber PM, Kim E, Sello J, Geiser J, Kennedy E, Arcadia C, Dombroski A, Oakley K, Chen SL, Tann H, Rubenstein BM

Multicomponent molecular memory.

Nature communications

Arcadia CE, Kennedy E, Geiser J, Dombroski A, Oakley K, Chen SL, Sprague L, Ozmen M, Sello J, Weber PM, Reda S, Rose C, Kim E, Rubenstein BM, Rosenstein JK

Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins.

eLife

Morgens DW, Chan C, Kane AJ, Weir NR, Li A, Dubreuil MM, Tsui CK, Hess GT, Lavertu A, Han K, Polyakov N, Zhou J, Handy EL, Alabi P, Dombroski A, Yao D, Altman RB, Sello JK, Denic V, Bassik MC

Analysis of vertebrate vision in a 384-well imaging system.

Scientific reports

Thorn RJ, Dombroski A, Eller K, Dominguez-Gonzalez TM, Clift DE, Baek P, Seto RJ, Kahn ES, Tucker SK, Colwill RM, Sello JK, Creton R

Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation.

Nature communications

McCarroll MN, Gendelev L, Kinser R, Taylor J, Bruni G, Myers-Turnbull D, Helsell C, Carbajal A, Rinaldi C, Kang HJ, Gong JH, Sello JK, Tomita S, Peterson RT, Keiser MJ, Kokel D

A peculiar IclR family transcription factor regulates para-hydroxybenzoate catabolism in Streptomyces coelicolor.

Nucleic acids research

Zhang R, Lord DM, Bajaj R, Peti W, Page R, Sello JK

Structurally optimized analogs of the retrograde trafficking inhibitor Retro-2cycl limit Leishmania infections.

PLoS neglected tropical diseases

Craig E, Huyghues-Despointes CE, Yu C, Handy EL, Sello JK, Kima PE

Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.

ACS infectious diseases

Totaro KA, Barthelme D, Simpson PT, Jiang X, Lin G, Nathan CF, Sauer RT, Sello JK

A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus.

PloS one

Arvanitis M, Li G, Li DD, Cotnoir D, Ganley-Leal L, Carney DW, Sello JK, Mylonakis E

Highly Dynamic Interactions Maintain Kinetic Stability of the ClpXP Protease During the ATP-Fueled Mechanical Cycle.

ACS chemical biology

Amor AJ, Schmitz KR, Sello JK, Baker TA, Sauer RT

Examination of a Structural Model of Peptidomimicry by Cyclic Acyldepsipeptide Antibiotics in Their Interaction with the ClpP Peptidase.

Chembiochem : a European journal of chemical biology

Carney DW, Schmitz KR, Scruse AC, Sauer RT, Sello JK

Substrate-guided optimization of the syringolins yields potent proteasome inhibitors with activity against leukemia cell lines.

Bioorganic & medicinal chemistry

Totaro KA, Barthelme D, Simpson PT, Sauer RT, Sello JK

Genetic and Proteomic Analyses of Pupylation in Streptomyces coelicolor.

Journal of bacteriology

Compton CL, Fernandopulle MS, Nagari RT, Sello JK

Fragment-Based Strategy for Investigating and Suppressing the Efflux of Bioactive Small Molecules.

ACS infectious diseases

Compton CL, Carney DW, Groomes PV, Sello JK

Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery.

Proceedings of the National Academy of Sciences of the United States of America

Schmitz KR, Carney DW, Sello JK, Sauer RT

A simple fragment of cyclic acyldepsipeptides is necessary and sufficient for ClpP activation and antibacterial activity.

Chembiochem : a European journal of chemical biology

Carney DW, Compton CL, Schmitz KR, Stevens JP, Sauer RT, Sello JK

Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses.

Bioorganic & medicinal chemistry

Carney DW, Nelson CD, Ferris BD, Stevens JP, Lipovsky A, Kazakov T, DiMaio D, Atwood WJ, Sello JK

Efficient and regiospecific syntheses of peptides with piperazic and dehydropiperazic acids via a multicomponent reaction.

Organic letters

Handy EL, Totaro KA, Lin CP, Sello JK

Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity.

Journal of the American Chemical Society

Carney DW, Schmitz KR, Truong JV, Sauer RT, Sello JK

A retrograde trafficking inhibitor of ricin and Shiga-like toxins inhibits infection of cells by human and monkey polyomaviruses.

mBio

Nelson CD, Carney DW, Derdowski A, Lipovsky A, Gee GV, O'Hara B, Williard P, DiMaio D, Sello JK, Atwood WJ

Antibacterial activity of and resistance to small molecule inhibitors of the ClpP peptidase.

ACS chemical biology

Compton CL, Schmitz KR, Sauer RT, Sello JK

Genome Sequence of Streptomyces viridosporus Strain T7A ATCC 39115, a Lignin-Degrading Actinomycete.

Genome announcements

Davis JR, Goodwin L, Teshima H, Detter C, Tapia R, Han C, Huntemann M, Wei CL, Han J, Chen A, Kyrpides N, Mavrommatis K, Szeto E, Markowitz V, Ivanova N, Mikhailova N, Ovchinnikova G, Pagani I, Pati A, Woyke T, Pitluck S, Peters L, Nolan M, Land M, Sello JK