Jason Sello, PhD | UCSF Center for TB

Proteasomes accumulate in the plant apoplast where they participate in microbe-associated molecular pattern (MAMP)-triggered pathogen defense.

Frontiers in medicine

Karimi HZ, Chen KE, Karinshak M, Gu X, Sello JK, Vierstra RD

Total Syntheses of Cyclomarin and Metamarin Natural Products.

Fei F, Lun S, Saxena A, Raghavan M, DeRisi JL, Bishai WR, Sello JK

A Multimodal, In Vivo Approach for Assessing Structurally and Phenotypically Related Neuroactive Molecules.

McCarroll MN, Sisko E, Gong JH, Teng J, Taylor J, Myers-Turnbull D, Young D, Burley G, Pierce LX, Hibbs RE, Kokel D, Sello JK

Small molecules restore azole activity against drug-tolerant and drug-resistant Candida isolates.

Alabi PE, Gautier C, Murphy TP, Gu X, Lepas M, Aimanianda V, Sello JK, Ene IV

Hydroxyl-Rich Hydrophilic Endocytosis-Promoting Peptide with No Positive Charge.

Wang S, Li Z, Aispuro D, Guevara N, Van Valkenburgh J, Chen B, Zhou X, McCarroll MN, Ji F, Cong X, Sarkar P, Chaudhuri R, Guo Z, Perkins NP, Shao S, Sello JK, Chen K, Xue M

Acyldepsipeptide Antibiotics and a Bioactive Fragment Thereof Differentially Perturb Mycobacterium tuberculosis ClpXP1P2 Activity in vitro.

Schmitz KR, Handy EL, Compton CL, Gupta S, Bishai WR, Sauer RT, Sello JK

Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections.

Craig E, Calarco A, Conte R, Ambrogi V, d'Ayala GG, Alabi P, Sello JK, Cerruti P, Kima PE

Discovery of Retro-1 Analogs Exhibiting Enhanced Anti-vaccinia Virus Activity.

The Lancet. Infectious diseases

Priyamvada L, Alabi P, Leon A, Kumar A, Sambhara S, Olson VA, Sello JK, Satheshkumar PS

Principles of Information Storage in Small-Molecule Mixtures.

Rosenstein JK, Rose C, Reda S, Weber PM, Kim E, Sello J, Geiser J, Kennedy E, Arcadia C, Dombroski A, Oakley K, Chen SL, Tann H, Rubenstein BM

Multicomponent molecular memory.

Frontiers in medicine

Arcadia CE, Kennedy E, Geiser J, Dombroski A, Oakley K, Chen SL, Sprague L, Ozmen M, Sello J, Weber PM, Reda S, Rose C, Kim E, Rubenstein BM, Rosenstein JK

Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins.

AIDS (London, England)

Morgens DW, Chan C, Kane AJ, Weir NR, Li A, Dubreuil MM, Tsui CK, Hess GT, Lavertu A, Han K, Polyakov N, Zhou J, Handy EL, Alabi P, Dombroski A, Yao D, Altman RB, Sello JK, Denic V, Bassik MC

Analysis of vertebrate vision in a 384-well imaging system.

The Lancet. Microbe

Thorn RJ, Dombroski A, Eller K, Dominguez-Gonzalez TM, Clift DE, Baek P, Seto RJ, Kahn ES, Tucker SK, Colwill RM, Sello JK, Creton R

Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation.

Frontiers in medicine

McCarroll MN, Gendelev L, Kinser R, Taylor J, Bruni G, Myers-Turnbull D, Helsell C, Carbajal A, Rinaldi C, Kang HJ, Gong JH, Sello JK, Tomita S, Peterson RT, Keiser MJ, Kokel D

A peculiar IclR family transcription factor regulates para-hydroxybenzoate catabolism in Streptomyces coelicolor.

Zhang R, Lord DM, Bajaj R, Peti W, Page R, Sello JK

Structurally optimized analogs of the retrograde trafficking inhibitor Retro-2cycl limit Leishmania infections.

Craig E, Huyghues-Despointes CE, Yu C, Handy EL, Sello JK, Kima PE

Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.

AIDS and behavior

Totaro KA, Barthelme D, Simpson PT, Jiang X, Lin G, Nathan CF, Sauer RT, Sello JK

A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus.

Research Square

Arvanitis M, Li G, Li DD, Cotnoir D, Ganley-Leal L, Carney DW, Sello JK, Mylonakis E

Highly Dynamic Interactions Maintain Kinetic Stability of the ClpXP Protease During the ATP-Fueled Mechanical Cycle.

Amor AJ, Schmitz KR, Sello JK, Baker TA, Sauer RT

Examination of a Structural Model of Peptidomimicry by Cyclic Acyldepsipeptide Antibiotics in Their Interaction with the ClpP Peptidase.

Carney DW, Schmitz KR, Scruse AC, Sauer RT, Sello JK

Substrate-guided optimization of the syringolins yields potent proteasome inhibitors with activity against leukemia cell lines.

Totaro KA, Barthelme D, Simpson PT, Sauer RT, Sello JK

Genetic and Proteomic Analyses of Pupylation in Streptomyces coelicolor.

Compton CL, Fernandopulle MS, Nagari RT, Sello JK

Fragment-Based Strategy for Investigating and Suppressing the Efflux of Bioactive Small Molecules.

AIDS and behavior

Compton CL, Carney DW, Groomes PV, Sello JK

Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery.

Journal of immigrant and minority health

Schmitz KR, Carney DW, Sello JK, Sauer RT

A simple fragment of cyclic acyldepsipeptides is necessary and sufficient for ClpP activation and antibacterial activity.

Carney DW, Compton CL, Schmitz KR, Stevens JP, Sauer RT, Sello JK

Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses.

Carney DW, Nelson CD, Ferris BD, Stevens JP, Lipovsky A, Kazakov T, DiMaio D, Atwood WJ, Sello JK

Efficient and regiospecific syntheses of peptides with piperazic and dehydropiperazic acids via a multicomponent reaction.

Handy EL, Totaro KA, Lin CP, Sello JK

Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity.

Carney DW, Schmitz KR, Truong JV, Sauer RT, Sello JK

A retrograde trafficking inhibitor of ricin and Shiga-like toxins inhibits infection of cells by human and monkey polyomaviruses.

Nelson CD, Carney DW, Derdowski A, Lipovsky A, Gee GV, O'Hara B, Williard P, DiMaio D, Sello JK, Atwood WJ

Antibacterial activity of and resistance to small molecule inhibitors of the ClpP peptidase.

Compton CL, Schmitz KR, Sauer RT, Sello JK

Genome Sequence of Streptomyces viridosporus Strain T7A ATCC 39115, a Lignin-Degrading Actinomycete.

Davis JR, Goodwin L, Teshima H, Detter C, Tapia R, Han C, Huntemann M, Wei CL, Han J, Chen A, Kyrpides N, Mavrommatis K, Szeto E, Markowitz V, Ivanova N, Mikhailova N, Ovchinnikova G, Pagani I, Pati A, Woyke T, Pitluck S, Peters L, Nolan M, Land M, Sello JK