
Associate Professor
M_MED-ZSFG-PULM
I lead the Mycobacterium tuberculosis research laboratory at Zuckerberg San Francisco General Hospital. The first goal of my laboratory is to fundamentally advance molecular diagnostics for pre-XDR and XDR TB by identifying new biomarkers of drug resistance in a rapid and unbiased manner, and by identifying causes that may decrease the efficiency of molecular methods such as the presence of hetero-resistance. The second goal is to determine the contribution of bacterial factors in the transmission and pathogenesis of tuberculosis.
UCSF Center for Tuberculosis Initiatives:
TB RAMP Mentor / Executive Committee Member
Publications
Adherence trajectory as an on-treatment risk indicator among drug-resistant TB patients in the Philippines.
Research Square
The Role of C-Reactive Protein as a Triage Tool for Pulmonary Tuberculosis in Children.
Cell systems
The spectrum of tuberculosis disease in an urban Ugandan community and its health facilities.
The American journal of tropical medicine and hygiene
A Prospective Evaluation of Xpert MTB/RIF Ultra for Childhood Pulmonary Tuberculosis in Uganda.
Cell systems
Tuberculosis Associated with HIV Infection.
N_IHA Operations
Empiric treatment of pulmonary TB in the Xpert era: Correspondence of sputum culture, Xpert MTB/RIF, and clinical diagnoses.
Research Square
Reference set of Mycobacterium tuberculosis clinical strains: A tool for research and product development.
Research Square
Interplay of strain and race/ethnicity in the innate immune response to M. tuberculosis.
Research Square
Spatial overlap links seemingly unconnected genotype-matched TB cases in rural Uganda.
Research Square
Clinical and bacteriological characteristics associated with clustering of multidrug-resistant tuberculosis.
JCI insight
Impact of Euro-American sublineages of Mycobacterium tuberculosis on new infections among named contacts.
JCI insight
Adaptation of Mycobacterium tuberculosis to Impaired Host Immunity in HIV-Infected Patients.
The Journal of antimicrobial chemotherapy
Serum biomarkers of treatment response within a randomized clinical trial for pulmonary tuberculosis.
M_MED-CORE-HOSP
Reduced sensitivity of the QuantiFERON(®) test in diabetic patients with smear-negative tuberculosis.
JCI insight
Use of 16S rRNA gene for identification of a broad range of clinically relevant bacterial pathogens.
Research Square
Genomic epidemiology of multidrug-resistant Mycobacterium tuberculosis during transcontinental spread.
The Journal of antimicrobial chemotherapy
Association between diabetes mellitus and tuberculosis in United States-born and foreign-born populations in San Francisco.
Research Square
Pyrazinamide resistance, Mycobacterium tuberculosis lineage and treatment outcomes in San Francisco, California.
Research Square
Sublineages of lineage 4 (Euro-American) Mycobacterium tuberculosis differ in genotypic clustering.
JCI insight
Use of whole genome sequencing to determine the microevolution of Mycobacterium tuberculosis during an outbreak.
Research Square
Impact of isoniazid resistance-conferring mutations on the clinical presentation of isoniazid monoresistant tuberculosis.
Research Square
Mycobacterium tuberculosis lineage--what's in your lungs?
The American journal of tropical medicine and hygiene
The role of speciation in positive Lowenstein-Jensen culture isolates from a high tuberculosis burden country.
Research Square
Determinants of multidrug-resistant tuberculosis clusters, California, USA, 2004-2007.
Journal of general internal medicine
Influence of M. tuberculosis lineage variability within a clinical trial for pulmonary tuberculosis.
Research Square
Tuberculosis-related deaths within a well-functioning DOTS control program.
Journal of general internal medicine
rpoB Gene mutations in rifampin-resistant Mycobacterium tuberculosis identified by polymerase chain reaction single-stranded conformational polymorphism.
Journal of general internal medicine
User's guide to tuberculosis resources on the internet.
The American journal of tropical medicine and hygiene
Drug resistance among acid-fast bacilli.
M_PEDS-INFECTIOUS DISEASE
Trypanosoma brucei rhodesiense infection imported to Mexico from a tourist resort in Kenya.
The American journal of tropical medicine and hygiene