QBI Director and Professor
P_Bioengineering
+1 415 476-2980
My lab at UCSF focuses on developing and applying quantitative, systematic proteomic and genetic approaches to study complex biological and biomedical problems. At present time, my group is focused on studying cancer, infectious disease, including tuberculosis, and psychiatric disorders.
Krogen Lab: https://kroganlab.ucsf.edu/krogan-lab
Publications
Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models.
Journal of medicinal chemistry
Large scale prospective evaluation of co-folding across 557 Mac1-ligand complexes and three virtual screens.
bioRxiv : the preprint server for biology
Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy In Vivo.
Journal of medicinal chemistry
Functional diversification of the cephalopod proteome by RNA-editing.
bioRxiv : the preprint server for biology
Combinatorial protein engineering identifies potent CRISPR activators with reduced toxicity.
Nature communications
The lactate sensor NDRG3 decelerates ER-to-Golgi transport through interaction with the long isoform of syntaxin-5.
Proceedings of the National Academy of Sciences of the United States of America
Pharmacological reprogramming of plitidepsin as a SARS-CoV-2 inhibitor.
Molecular aspects of medicine
Lysosomal proteomics reveals mechanisms of neuronal APOE4-associated lysosomal dysfunction.
Autophagy
Human genetic variation associates with infection by derived Ugandan M. tuberculosis lineage.
medRxiv : the preprint server for health sciences
Mycobacterium tuberculosis triggers reduced inflammatory cytokine responses and virulence in mice lacking Tax1bp1.
PLoS pathogens
Selective RNA sequestration in biomolecular condensates directs cell fate transitions.
Nature biotechnology
Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy in vivo.
bioRxiv : the preprint server for biology
Rare coding mutations identify 36 large-effect risk genes in obsessive-compulsive disorder and chronic tic disorders.
medRxiv : the preprint server for health sciences
Ebola virus VP35 NNLNS motif modulates viral RNA synthesis and MIB2-mediated signaling.
Proceedings of the National Academy of Sciences of the United States of America
Redefining druggable targets with artificial intelligence.
Nature biotechnology
Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response.
bioRxiv : the preprint server for biology
Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication.
bioRxiv : the preprint server for biology
Ebola virus VP35 NNLNS motif modulates viral RNA synthesis and MIB2-mediated signaling.
bioRxiv : the preprint server for biology
Programmable translational inhibition by a molecular glue-oligonucleotide conjugate.
bioRxiv : the preprint server for biology
Inference of differential kinase interaction networks with KINference.
Bioinformatics (Oxford, England)
A transcriptomic, proteomic, and functional genetic atlas dissects neurofibromin function in the peripheral nervous system.
Proceedings of the National Academy of Sciences of the United States of America
Paracrine Signals from HIV-1 Infected Immune Cells Reprogram Cervical Cancer Pathways.
bioRxiv : the preprint server for biology
AlphaFold models of host-pathogen interactions elucidate the prevalence and structural modes of molecular mimicry.
bioRxiv : the preprint server for biology
The Mediator Kinase Module regulates cell cycle re-entry and transcriptional responses following DNA damage.
bioRxiv : the preprint server for biology
Selective RNA sequestration in biomolecular condensates directs cell fate transitions.
bioRxiv : the preprint server for biology
Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy.
Science advances
The Chlamydia effector Dre1 binds dynactin to reposition host organelles during infection.
Cell reports
Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6.
PLoS pathogens
Lysosomal proteomics reveals mechanisms of neuronal apoE4associated lysosomal dysfunction.
IJTLD open
Central control of dynamic gene circuits governs T cell rest and activation.
SSM - Health Systems
SARS-CoV-2 evolution balances conflicting roles of N protein phosphorylation.
Journal of acquired immune deficiency syndromes (1999)
Discovery and significance of protein-protein interactions in health and disease.
Journal of primary care & community health
MerlinS13 phosphorylation regulates meningioma Wnt signaling and magnetic resonance imaging features.
Frontiers in medicine
Fibrin drives thromboinflammation and neuropathology in COVID-19.
SSM - Health Systems
Fate of telomere entanglements is dictated by the timing of anaphase midregion nuclear envelope breakdown.
Frontiers in medicine
An automated proximity proteomics pipeline for subcellular proteome and protein interaction mapping.
IJTLD open
CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells.
Frontiers in Immunology
Spatial control of sensory adaptation modulates mechanosensing in Pseudomonas aeruginosa.
IJTLD open
Epigenetic reprogramming shapes the cellular landscape of schwannoma.
Frontiers in medicine
Hepatitis C virus infects and perturbs liver stem cells.
Frontiers in Immunology
De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking.
Journal of primary care & community health
Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets.
Frontiers in medicine
Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis.
Statistical methods in medical research
SARS-CoV-2 variants evolve convergent strategies to remodel the host response.
Journal of primary care & community health
A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo.
Journal of acquired immune deficiency syndromes (1999)
Next-generation proteomics for quantitative Jumbophage-bacteria interaction mapping.
Frontiers in medicine
Cross-family small GTPase ubiquitination by the intracellular pathogen Legionella pneumophila.
IJTLD open
Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens.
Journal of acquired immune deficiency syndromes (1999)
Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3.
Frontiers in medicine
Lessons learned for pandemic preparedness: A collaborative network is imperative.
Statistical methods in medical research
Dengue virus NS5 degrades ERC1 during infection to antagonize NF-kB activation.
Journal of immigrant and minority health
MerlinS13 phosphorylation controls meningioma Wnt signaling and magnetic resonance imaging features.
Next-generation interaction proteomics for quantitative Jumbophage-bacteria interaction mapping.
IJTLD open
Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13.
IJTLD open
Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms.
AIDS (London, England)
Nuclear accumulation of host transcripts during Zika Virus Infection.
Journal of acquired immune deficiency syndromes (1999)
Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis.
IJTLD open
SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.
Journal of acquired immune deficiency syndromes (1999)
CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir.
Frontiers in Immunology
Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3.
Frontiers in medicine
Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities.
Journal of occupational and environmental hygiene
A functional map of HIV-host interactions in primary human T cells.
Frontiers in medicine
Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2.
SSM - Health Systems
Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.
IJTLD open
Leveraging modeling and simulation to optimize the therapeutic window for epigenetic modifier drugs.
Transcription factor protein interactomes reveal genetic determinants in heart disease.
Journal of primary care & community health
Brahma safeguards canalization of cardiac mesoderm differentiation.
SSM - Health Systems
Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission.
Statistical methods in medical research
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
Journal of primary care & community health
Evolution of enhanced innate immune evasion by SARS-CoV-2.
SSM - Health Systems
Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma.
The European respiratory journal
Caveolin-1 and Sox-2 are predictive biomarkers of cetuximab response in head and neck cancer.
Travel Medicine and Infectious Disease
Systems-level effects of allosteric perturbations to a model molecular switch.
SSM - Health Systems
Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy.
JAMA
Endosomal cAMP production broadly impacts the cellular phosphoproteome.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization.
Clinical Infectious Diseases
Chemical-genetic interrogation of RNA polymerase mutants reveals structure-function relationships and physiological tradeoffs.
Journal of the International Association of Providers of AIDS Care
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.
Journal of primary care & community health
The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D.
SSM - Health Systems
Creating collaboration by breaking down scientific barriers.
Journal of primary care & community health
Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant.
IJTLD open
SUMO is a pervasive regulator of meiosis.
AIDS (London, England)
Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses.
Journal of primary care & community health
SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling.
Journal of immigrant and minority health
Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses.
IJTLD open
Evaluation of SARS-CoV-2 serology assays reveals a range of test performance.
Nature biotechnology
SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in Cells.
IJTLD open
Envelope protein ubiquitination drives entry and pathogenesis of Zika virus.
SSM - Health Systems
Correction: Thioredoxin-related protein 32 is an arsenite-regulated thiol reductase of the proteasome 19 S particle.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Journal of primary care & community health
Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection.
Journal of primary care & community health
Test performance evaluation of SARS-CoV-2 serological assays.
Clinical Infectious Diseases
mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1.
Frontiers in medicine
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
SSM - Health Systems
A Quantitative Genetic Interaction Map of HIV Infection.
Journal of the International Association of Providers of AIDS Care
Dynamic post-translational modification profiling of Mycobacterium tuberculosis-infected primary macrophages.
AIDS (London, England)
The functional landscape of the human phosphoproteome.
Nature biotechnology
UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity.
SSM - Health Systems
Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen.
Statistical methods in medical research
Regulation of Skn7-dependent, oxidative stress-induced genes by the RNA polymerase II-CTD phosphatase, Fcp1, and Mediator kinase subunit, Cdk8, in yeast.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
Anti-CRISPR-Associated Proteins Are Crucial Repressors of Anti-CRISPR Transcription.
Journal of primary care & community health
Large dataset enables prediction of repair after CRISPR-Cas9 editing in primary T cells.
Nature biotechnology
PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization.
Journal of immigrant and minority health
ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.
Statistical methods in medical research
Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria.
Frontiers in Immunology
Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress.
Journal of immigrant and minority health
Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins.
Journal of the International Association of Providers of AIDS Care
Genetic analysis reveals functions of atypical polyubiquitin chains.
AIDS (London, England)
Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.
Journal of primary care & community health
Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication.
Journal of primary care & community health
The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein.
Frontiers in Immunology
EpCAM homo-oligomerization is not the basis for its role in cell-cell adhesion.
The Lancet. Microbe
Mycobacterial Mutagenesis and Drug Resistance Are Controlled by Phosphorylation- and Cardiolipin-Mediated Inhibition of the RecA Coprotease.
Journal of the International Association of Providers of AIDS Care
An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses.
Journal of the International Association of Providers of AIDS Care
The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.
Journal of primary care & community health
Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.
The Lancet. Microbe
The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.
AIDS (London, England)
Author Correction: SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses.
The Lancet. Microbe
The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells.
Journal of the International Association of Providers of AIDS Care
SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses.
The Lancet. Microbe
Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors.
Journal of acquired immune deficiency syndromes (1999)
Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1.
Clinical gerontologist
Mutations in the X-linked ATP6AP2 cause a glycosylation disorder with autophagic defects.
Clinical gerontologist
A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.
Travel Medicine and Infectious Disease
The Tyrosine Kinase Inhibitor Gefitinib Restricts Mycobacterium tuberculosis Growth through Increased Lysosomal Biogenesis and Modulation of Cytokine Signaling.
AIDS and behavior
SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency.
Statistical methods in medical research
The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity.
Journal of primary care & community health
An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells.
Journal of primary care & community health
PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription.
The Lancet. Microbe
Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction.
AIDS (London, England)
Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106.
AIDS (London, England)
Inhibition of CRISPR-Cas9 with Bacteriophage Proteins.
Journal of primary care & community health
A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors.
Journal of occupational and environmental hygiene
The mTOR Complex Controls HIV Latency.
Statistical methods in medical research
A Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export.
Statistical methods in medical research
The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing.
Journal of acquired immune deficiency syndromes (1999)
Non-degradative Ubiquitination of Protein Kinases.
Current opinion in cell biology
Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection.
Journal of cell science
Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.
Statistical methods in medical research
CDK11 in TREX/THOC Regulates HIV mRNA 3' End Processing.
Statistical methods in medical research
Discovery and functional characterization of a neomorphic PTEN mutation.
Journal of immigrant and minority health
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.
P_Pharmaceutical Chemistry
Prediction of Functionally Important Phospho-Regulatory Events in Xenopus laevis Oocytes.
Current opinion in cell biology
Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication.
AIDS (London, England)
Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection.
Statistical methods in medical research
The cancer cell map initiative: defining the hallmark networks of cancer.
Journal of the International Association of Providers of AIDS Care
Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.
AIDS (London, England)
A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay.
Journal of the International Association of Providers of AIDS Care
Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.
Journal of the International Association of Providers of AIDS Care
AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation.
Journal of immigrant and minority health
From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II.
Journal of primary care & community health
A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress.
Journal of the International Association of Providers of AIDS Care
Bringing it all together: big data and HIV research.
The Lancet regional health. Southeast Asia
The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat.
AIDS (London, England)
From systems to structure: bridging networks and mechanism.
Journal of the International Association of Providers of AIDS Care
CBFß stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression.
Journal of the International Association of Providers of AIDS Care
A gene ontology inferred from molecular networks.
Nature biotechnology
Dissection of DNA damage responses using multiconditional genetic interaction maps.
Journal of the International Association of Providers of AIDS Care
Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G.
Journal of acquired immune deficiency syndromes (1999)
HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold.
Journal of immigrant and minority health
Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models.
Journal of occupational and environmental hygiene
Systematic functional prioritization of protein posttranslational modifications.
Journal of primary care & community health
Hierarchical modularity and the evolution of genetic interactomes across species.
Journal of the International Association of Providers of AIDS Care
Comparative interaction networks: bridging genotype to phenotype.
Infectious microbes & diseases
Global landscape of HIV-human protein complexes.
SSM - Health Systems
Vif hijacks CBF-ß to degrade APOBEC3G and promote HIV-1 infection.
SSM - Health Systems
RNA polymerase II carboxyl-terminal domain phosphorylation regulates protein stability of the Set2 methyltransferase and histone H3 di- and trimethylation at lysine 36.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress.
Journal of immigrant and minority health
Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Journal of the International Association of Providers of AIDS Care
Phenotypic landscape of a bacterial cell.
Journal of primary care & community health
Functional overlap and regulatory links shape genetic interactions between signaling pathways.
Journal of primary care & community health
Individual lysine acetylations on the N terminus of Saccharomyces cerevisiae H2A.Z are highly but not differentially regulated.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
Quantitative genetic interactions reveal biological modularity.
Journal of primary care & community health
HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription.
Journal of the International Association of Providers of AIDS Care
A systematic characterization of Cwc21, the yeast ortholog of the human spliceosomal protein SRm300.
Host cell factors in HIV replication: meta-analysis of genome-wide studies.
Journal of acquired immune deficiency syndromes (1999)
Thioredoxin-related Protein 32 is an arsenite-regulated Thiol Reductase of the proteasome 19 S particle.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
Functional organization of the S. cerevisiae phosphorylation network.
Journal of primary care & community health
A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing.
Journal of the International Association of Providers of AIDS Care
A single SR-like protein, Npl3, promotes pre-mRNA splicing in budding yeast.
Journal of the International Association of Providers of AIDS Care
Functional maps of protein complexes from quantitative genetic interaction data.
Current opinion in cell biology
Mec1/Tel1 phosphorylation of the INO80 chromatin remodeling complex influences DNA damage checkpoint responses.
Journal of primary care & community health
H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex.
Journal of the International Association of Providers of AIDS Care
CCR4/NOT complex associates with the proteasome and regulates histone methylation.
Journal of immigrant and minority health
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map.
SSM - Health Systems
A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.
Journal of primary care & community health
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
SSM - Health Systems
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.
SSM - Health Systems
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.
Journal of primary care & community health
Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile.
Journal of primary care & community health
Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone.
Journal of primary care & community health
Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing.
Journal of the International Association of Providers of AIDS Care
The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
Interaction network containing conserved and essential protein complexes in Escherichia coli.
SSM - Health Systems
Proteasome involvement in the repair of DNA double-strand breaks.
Journal of the International Association of Providers of AIDS Care
INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair.
Journal of primary care & community health
The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II.
SSM - Health Systems
Interaction of Fcp1 phosphatase with elongating RNA polymerase II holoenzyme, enzymatic mechanism of action, and genetic interaction with elongator.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4.
Journal of immigrant and minority health
Exploration of essential gene functions via titratable promoter alleles.
Journal of primary care & community health
High-definition macromolecular composition of yeast RNA-processing complexes.
Journal of the International Association of Providers of AIDS Care
A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1.
Journal of the International Association of Providers of AIDS Care
A panoramic view of yeast noncoding RNA processing.
Journal of primary care & community health
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation.
Journal of the International Association of Providers of AIDS Care
Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter.
Journal of the International Association of Providers of AIDS Care
COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
COMPASS: a complex of proteins associated with a trithorax-related SET domain protein.
Journal of immigrant and minority health