
QBI Director and Professor
P_Bioengineering
+1 415 476-2980
My lab at UCSF focuses on developing and applying quantitative, systematic proteomic and genetic approaches to study complex biological and biomedical problems. At present time, my group is focused on studying cancer, infectious disease, including tuberculosis, and psychiatric disorders.
Krogen Lab: https://kroganlab.ucsf.edu/krogan-lab
Publications
Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy.
Science advances
The Chlamydia effector Dre1 binds dynactin to reposition host organelles during infection.
Cell reports
Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6.
PLoS pathogens
Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response.
bioRxiv : the preprint server for biology
An automated proximity proteomics pipeline for subcellular proteome and protein interaction mapping.
MerlinS13 phosphorylation controls meningioma Wnt signaling and magnetic resonance imaging features.
Leveraging modeling and simulation to optimize the therapeutic window for epigenetic modifier drugs.
Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission.
Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses.
The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein.
Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.
P_Pharmaceutical Chemistry