Clinical and Population Health Core

Progress towards meeting global public health tuberculosis (TB) targets for reductions in incidence, mortality and socioeconomic consequences have been slow, and in some cases reversed due to the recent COVID-19 pandemic.

Without reinvigorating TB clinical and population health research with an infusion of new investigators, novel perspectives, cutting-edge innovation, and rigorous implementation strategies we remain at risk of allowing the TB pandemic to continue unabated.

The goal of the Clinical Science and Population Health Core is to augment existing UCSF and UCB resources to accelerate clinical and population health research. We want to engage New Investigators with novel ideas, reduce regulatory barriers to research while maintaining scientific rigor, and increasing access to clinical and public health data and analytic resources so that more people can join the fight to end TB.

Specific Aims:

• Provide consultation related to substantive TB clinical, translational, and population health methods
• Curate and maintain a searchable data registry of clinical studies led by UCSF-UCB TB clinical researchers alongside publicly-available resources
• Leverage a Global UC TRAC community advisory board to integrate community engagement into every aspect of our research program
• Mentor new investigators (NIs) in the conduct of TB clinical research

Consultation Service for UCSF and UC Berkeley TB researchers

Consultation service is offered to UCSF and UC Berkeley TB researchers, as well as those new to TB, via the UCSF Clinical & Translational Science Institute (CTSI) across a broad range of research methods.
Submit a request for consultation

Data Catalogue

This searchable data catalogue curates standardized information on datasets found across UCSF, UC Berkeley, and UC Irvine.

UC TB-CAB

The UC TB-CAB is dedicated to increasing community involvement in TB research conducted by University of California TB investigators at San Francisco and Berkeley. The UC TB-CAB acts in an advisory capacity to UC TRAC investigators and UC TRAC affiliated institutions to improve TB prevention, diagnosis, treatment, and care. The UC TB-CAB provides community-centered input on research priorities, study design, dissemination practices, and community-engagement strategies. Learn more about UC TB-CAB here.

Resources

• SEATRAC Advanced TB Research Training
  Courses presented during the University of Washington’s Advanced TB Research Training Course 9/18-22/23. Accessible for free through the course website.
• TB Portals
  Managed by NIH to facilitate meta-domain and domain specific TB data exploration and analysis. The TB Portals database contains linked clinical, bacterial genomic, and medical imaging data from TB patient cases.
• TB-IPD platform
  The TB treatment individual patient data platform (TB-IPD) is a collaborative initiative to support the generation of reliable evidence on the treatment of TB to inform future TB treatment guidelines. It is supported by the WHO Global TB Programme and maintained by UCL.
• TB-PACTS
  Repository of data from TB treatment trials. There are currently data from 26 clinical trials from phase I through phase III, as well as a few latent TB trials.
• WHO TB Research Tracker
  Online platform by the WHO Global Tuberculosis Programme to track progress in the development of new treatment regiments, andvaccines as well as operational research projects designed to improve TB prevention, treatment, and care.