UCSF’s innovative, collaborative approach to patient care, research and education spans disciplines across the life sciences, making it a world leader in scientific discovery and its translation to improving health.
My research focusses on the causative agent of tuberculosis, Mycobacterium tuberculosis: I apply a combination of wet work and bioinformatics to investigate genomic and transcriptional associates of drug resistance, clinical outcomes, and patient infectiousness. See www.SemiQuant.com for more information.
I am the Medical Director of the San Francisco Department of Public Health (SFDPH) Tuberculosis Clinic at Ward 94 located at Zuckerberg San Francisco General Hospital. In addition to overseeing the clinical team in San Francisco, I also have experience working overseas in tuberculosis surveillance. I am board-certified in internal medicine and infectious diseases and continue to consult on infectious diseases at the San Francisco Veterans Administration Medical Center.
I specialize in HIV/AIDS and have clinical responsibilities including outpatient services at the San Francisco General Hospital HIV clinic as well as inpatient services on the HIV/AIDS, general medicine, and infectious diseases consult services. I direct the HIV Clinical Trials Group at SFGH, which conducts investigator-initiated and industry HIV trials. I am site investigator for the Adult AIDS Clinical Trials Group (ACTG), and my research interests include HIV and TB coinfection, development of novel TB diagnostics, and HIV and viral hepatitis coinfection.
My research focuses on elucidating the drivers of the large latent TB reservoir in East Africa and developing interventions to prevent TB infection and to improve the TB care continuum for HIV-infected and uninfected children and adults living in sub-Saharan Africa. Clinically, I am the Assistant Director of the Infectious Diseases Clinic at ZSFG, and direct the SALUD clinic, a clinic within the Positive Health Practice "Ward 86" at ZSFG, that is dedicated to providing multidisciplinary care to monolingual Spanish-speaking HIV-infected patients.
Joseph ("Mike") McCune is a professor of medicine at the University of California, San Francisco (UCSF). He received his AB degree from Harvard College in 1975, his PhD degree from Rockefeller University in 1981, and his MD degree from Cornell University Medical College in 1982. He completed his residency in internal medicine in 1984 and did fellowship training in infectious diseases at UCSF. He is board certified in internal medicine.
I have a particular interest in clinical management of multidrug resistant tuberculosis (MDR-TB) in high HIV burden settings in Southern Africa. My research includes the development of non-invasive pharmacokinetic measures to enhance MDR-TB drug development and clinical trials. I am a member of the AIDS Clinical Trials Group TB Transformative Science Group, and have specialized training in epidemiology, statistical prediction, and diagnostic test evaluation. I am a specialty editor for respiratory diseases at PLoS Medicine.