UCSF’s innovative, collaborative approach to patient care, research and education spans disciplines across the life sciences, making it a world leader in scientific discovery and its translation to improving health.
With an emphasis on TB therapeutics, my research uses computational methods to study the dynamic interplay between disease progression, drug and biomarker response across relevant scales (molecule, cell, tissue, organ & whole body) in order to determine causal links underlying variability in (safety and efficacy) clinical outcomes.
Co-Director, UC TRAC Clinical & Population Health Science Core
Associate Professor
Medicine
I focus on two main areas of TB research: 1) Implementation and operational research to improve programmatic outcomes of TB diagnostic and treatment care using evidence-based guidelines; and 2) Social protection research aimed at improving patient and public health outcomes by implementing social protection interventions to overcome socioeconomic barriers to TB care and evaluating both economic and TB outcomes of these approaches.
Tuberculosis (TB) disease, caused by infection with the intracellular pathogen Mycobacterium tuberculosis (Mtb) remains a leading cause of mortality globally. Interestingly, only 5-10% of Mtb-exposed individuals are estimated to develop active TB in their lifetime, thus posing host-specific factors as mediators of risk of progression to disease. These host factors include several defects in innate and adaptive immunity, metabolic dysregulation, co-infections and comorbidities, and genetic polymorphisms that could mediate susceptibility to TB disease.
Pragmatic and goal oriented pharmaceutical scientist (PharmD, PhD) with a strong clinical and preclinical background. Having worked in different environments helped me developing a unique set of soft skills including being a team player, a critical thinker and a problem solver. I work organized and I am always eager to learn and expand my knowledge. My research interests include infectious diseases, mechanistic pharmacokinetics, pharmacokinetic/pharmacodynamic modeling and simulation, and model-informed drug development.
Dr. Velásquez is an Assistant Professor of Medicine in the Division of HIV, Infectious Diseases, and Global Medicine at the University of California, San Francisco. He is an infectious disease physician and clinical researcher focused on tuberculosis (TB) therapeutics. Based at the UCSF Center for Tuberculosis (tb.ucsf.edu), he works with the endTB consortium (endTB.org), the SMART4TB consortium (tbcenter.jhu.edu/smart4tb), and the AIDS Clinical Trials Group on Phase 2 and Phase 3 randomized controlled trials evaluating new shortened regimens for drug-susceptible and drug-resistant TB.