UCSF’s innovative, collaborative approach to patient care, research and education spans disciplines across the life sciences, making it a world leader in scientific discovery and its translation to improving health.
I hold a Ph.D. from the Max-Planck Institute in Berlin. Before joining the UCSF Faculty, I was a Member of the Basel Institute for Immunology, Basel, Switzerland, and a Principal Investigator at the Max-Planck Institute in Tübingen, Germany.
I am a social scientist who uses qualitative and mixed methods within TB screening, diagnostics, and therapeutics research. My research interests focus on understanding trajectories of mental health during TB diagnosis and treatment, the influence of mental health on engagement with the TB diagnosis and care cascade, and implementation science approaches for the integration of mental health services into TB care and treatment.
My lab employs genomic technologies, including metagenomic next-generation sequencing, immune repertoire sequencing, bulk and single cell transcriptomics and phage display assays for viral and autoantibody detection to better understand the pathophysiology of a variety of neuroinflammatory syndromes ranging from multiple sclerosis to infectious and autoimmune meningitis and encephalitis.
My research is focused on identifying accurate and affordable TB diagnostic tools to improve the efficiency of TB diagnosis and delivery of TB preventive therapy for high-risk populations in resource-limited settings. I have experience in leading international studies of diagnostic accuracy and longitudinal cohort studies.
Dr. Zha is a Pulmonary and Critical Care physician scientist. She specializes in the care of patients with bronchiectasis and nontuberculous mycobacterial pulmonary infections. She cofounded the Bronchiectasis and Pulmonary NTM Clinic at UCSF and attends in the Parnassus intensive care units. In addition, Dr. Zha conducts research that focuses on understanding the macrophage responses to mycobacterial infections, and how environmental and genetic influences alter these responses.